{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_gcZnjHbssViRRSwT8KDqb4qbXgwiKKoyZe3sIqJ_UQ0.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022khemmew0K+GwuBgmVIcrzGOAwqMDxe\\\\\\\\\\\\\\\/tVVZ9dAzPHNzVbm2HFtlNV3YinS0vZ3aHU2zByW\\\\\\\\\\\\\\\/uXpSXpdu9FFu8KRq7vWLuEI9HUFLtHLXNOsOhK\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/6yJcwA660bc35YtLFYZuYORpGODxGTEvP0Jombx+lsXqcGrFxz+ZL2iIqTWZBbo\\\\\\\\\\\\\\\/N4xZr6ZDHWiA\\\\\\\\\\\\\\\/LdgiaF4Nm2gCyZwX82jZj4cxOWDPbWFWMvu3wjKW6CfFbWWLQwOs5nhK0dqDNd+cqxwSrmCrM3\\\\\\\\\\\\\\\/z2Exx+ACGqZ0WdBiMNRrdDO82T3HjTRDaHunJaHDATuL2G6ekZsoIpjEDc\\\\\\\\\\\\\\\/g+de9jl5M88R3Yq\\\\\\\\\\\\\\\/+SNYYWl6Xyzk19cmLrRvYt\\\\\\\\\\\\\\\/pNx6CODXGGrwMuh1adVuXW4ULs78JCpOw9rZsUEaqZDJ1EKuMkaAfLT3Kp+QPej76nd172+Q9oW+ka\\\\\\\\\\\\\\\/F+HDkwvjeHfN7rS96my0h1z9ODEPRYp1IDvdOKYPu7jLXruzaTBJL68OiwyKvF3VnvcZgWiAR1z8EisdZADrg7xzxQ9zffKMrU1BPGzmiZxAHwDERtEMx2zWAzCbFwBTRfwsHcNAR6mekU6azLgaPOy26szNugKMBhlkHFtt2oK549O9IH0pbWXyHfYRiXLOMin0olweT9HhHeDGogGWai\\\\\\\\\\\\\\\/+vj1zXPBU12Y8roai5NExvZ59D7+YFv9HvbuTkFMB1ZnV3QRhkkeohjWkRJ09JpTfYk68w\\\\\\\\\\\\\\\/BYyOqUcpYWOwsubNTGaoMwlVjumql5s4fxUAGGQRFi9t+eyC6fw5M56CKTqp\\\\\\\\\\\\\\\/+TeW5MqNFNfZxjXM2D82v\\\\\\\\\\\\\\\/bVkhXHEIbwInHumOZlhko1TGv5Co0xgjTEFdtXecs+q0WZFPYrWVbmAmuRDrUBOWhnXZw\\\\\\\\\\\\\\\/kFCy+X48VacH++IXWFN9KFU6r\\\\\\\\\\\\\\\/Z6HJtCh3oCBOxdpWUAsG9Q55Js8tiVwRm4k8MACEjz5G6zl3Fuh3lI\\\\\\\\\\\\\\\/jhjnScOMolIYwWy46cANKaIObvVnFZxBKI\\\\\\\\\\\\\\\/3DVR6+YBGkE8AR67\\\\\\\\\\\\\\\/Fnpf2nrLL0Q48IgFYx9LreOuVggHh2L1+6td19dYkMPJRMfL3Ffb1EN2E\\\\\\\\\\\\\\\/uYh97mLiQ5hsP8t\\\\\\\\\\\\\\\/UL59n4y9oBUquYG2JkHj1d\\\\\\\\\\\\\\\/Ln1dLojdu1\\\\\\\\\\\\\\\/NqyLCs2vEfyHnOBv1J9PrlKs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/9enSWnbKRYCln1v8PTsATYBzByVTtfb9BFsqvLoPEacJqRJTUmh+eSEftLdxs2fkW1ESEiziJF07JTJPBeYMM0QE6Nm2DpxKKV+0NYTWW5lWjpKUmAMXDvEAYSEAuAeTv6BMHn+rgVVTETM19brWc9OTqHPSn8L72VySzc4vPHBLd0x08wf87+MX963ctHjAqQwgq3qzB8YCRMjvsEXLcdl+OWxp0KutG+aExPup6LL+y3NFAhESGElrvmQd5X1NERAW2MMT6uAxFgG24bsozI9I7Qp8oe3Zxjrw\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/zO4m6DeJ6aUsOVlxdLccpb2l+XTSvYp7Jjj9sB+0yiVFwueRodiMGRup+diIjg9I5NMcW0TqG7wT2q5iEnAVcVbonKHY2lPzIraIEsvywyEJ2GPLNmkN35o0mX7QPRJL1SBweBLFpHDgqJ\\\\\\\\\\\\\\\/hMjo5eS6P+8QTLIXJJwSaE3cq9uydhgp9KpiV6h5HRrJTOQdjY1wA2VOKY5GVUSyjWcxY58HEnkH6U60ptoR7HkCfRXeqEqW94jhtR8zdduf\\\\\\\\\\\\\\\/9b1Yc98uAw2\\\\\\\\\\\\\\\/R+Y3FrUKU2T6Jxs1A4jkKnUZQ1sSOmvqFjR\\\\\\\\\\\\\\\/qjm2n0XH08ti9CzpdToQZv8hwjUobaz1RmTS88ZgA5ZTDsuA8RSMWYf67B3qieGRvlQNwYmUH7+s5s2Z\\\\\\\\\\\\\\\/tTqy83btI2SZe\\\\\\\\\\\\\\\/I+nQOGpzKmo++GZQcg0CO8HcgqGmMIJ19aVmFwDA1XRsFYGiz1WiuQxHtyiT0O7\\\\\\\\\\\\\\\/+9otjvwmWDadjdqbJkpvTVUOAZ43FIibtRb78QkYQt5UUUBXsGXEfocVuFG0lwLhOZ3HOfhpdtSKo5THHxC4EyIzN\\\\\\\\\\\\\\\/9uPCZTzzX1kcy6gmyjCDCO1vhyTq31jjk0EhoD7v0xjwteWuimxOzc0e36OhIQiWo8L7D9RiFpf8iHh0Wrdw80gJKAggGMgFXeym\\\\\\\\\\\\\\\/V5UYd2d8yEb2v7Nsj+WMfYtMpp1R08Vw\\\\\\\\\\\\\\\/ujXtsvm643HPDCu68yHs6EcbBAvNCNRiVujAY\\\\\\\\\\\\\\\/lFOKF5Cp52eI\\\\\\\\\\\\\\\/55HlUEmJsgv0zPMh8ypcBdc2m9EIep3b+2\\\\\\\\\\\\\\\/ZrZVutaZ1LC3wfVP553MFP3JReDSasvG0Le2veVKc3ZGt7J7o5igpRSIEHhHmjdPIZe4lOGbrw9EuybiCWbO6F59vSwQt0B+oP8iQGb\\\\\\\\\\\\\\\/tFKluvLtcClbqRKMVFc0rCgT5maqsEN\\\\\\\\\\\\\\\/fIRabXmg4kDXycJq26ob8+rXDt4alZ93youS4mD3mh0rnR7fL1gUvmrxZGWsMH9Wecepn2sWhbhrss5ynMC3jNXKP\\\\\\\\\\\\\\\/OXhbWY+T0Z3M910jcJkfYPm0QVlLuIYgHZoHhod5HgQMwWwiVBlZjpjG7WgyFUtdQSkAk4ktRZAdVtrISCLFwSbMjbBBC+w++O8Gb01l1cr+Lg8QaucIqZTpojkZhBR8O3iUtU9Ri5zxgBIKwDSPPVErJoi4pmoVMu5\\\\\\\\\\\\\\\/kljgJZ\\\\\\\\\\\\\\\/u+7eCP5CqcHQKWTAcSXz0sbCNbNpFZ3iF5Fy3hulSDLXXLbVjm9GJteWD\\\\\\\\\\\\\\\/EtcaNE6CczFGKOefqHWtRHwcLbfUnj5VKksAllY4Bv9gb1ipwrKmI7Janf0ffwNfXjvO5d+A\\\\\\\\\\\\\\\/mCNdu08TTNSvKnumQ\\\\\\\\\\\\\\\/2eaL0lJrBAhshb7BegQjNgqRto77SWimPd22rz6YzIJdLpUu\\\\\\\\\\\\\\\/j5HDr\\\\\\\\\\\\\\\/Yo3HF7LmwRa5Bu6Mswyrh1G8h9qBrCWIoH5fUtwC0x11AQMssVyIJXZRXqzKzjlqMom7L0PzNU3VaiQ7q15Mrry9\\\\\\\\\\\\\\\/7iw==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00226NGwjsPt1R7EbIsXXwo7xQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022df10f1d4f5db599ceff76a33cd640de8fa12a0c335e69cd92404bb850b4bca62\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e0637-6ret.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e0637-6ret.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node13698\u0022 data-node-nid=\u002213698\u0022 id=\u0022node-13698--2263401339\u0022 data-pisa=\u0022jitc;8\/1\/e0637-6ret\u0022 data-pisa-master=\u0022jitc;jitc-2020-0637-6ret\u0022 data-apath=\u0022\/jitc\/8\/1\/e0637-6ret.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003ERetracted\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2020;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E8:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee0637-6ret. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2020-0637-6ret \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EJanuary 11, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222020-05-13\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}