{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_M8BsRY25PLDHBensqRcUs1nEubvHeoGn5HSxBrIWeZs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221ILj144bBIfPNnJkt+KdCQp7UsSeHA6Tc5739STPTh79ebyEXX1bDjcMbGtp3kiEZEx4q8434RmMex6Bsfg2oM3x0XrNSiVp5tH3dHZl4DLuIAGQ8VpSHALVQxtRqbp3YZvrSG531+xNOaITaiT28nSQWTiB2PWFJv1U1UbBJbexhAluic0wIMV71KVcDv6tCGjXbIQLIpAWBO7rIsrNjIHjX45rmtdEprHlF2641msVEM4clifz2vos7ce149CxT0qeuvIAEmcj8sxdFwmDPa3YIQ5xUojbOuHJ+KMatC08youke9fy1ltOi5jqfYhMabMzfMtBtNIck28GNQ4C8SBq6OV+DBz22rct\\\\\\\\\\\\\\\/vYsCAlqrHAZ2sgAUo6smNSbwJmXm4KVsShsLrtlJssPN6Uw1c0VqlfNcwBS4ZEdM3eUC88R+xsUpWuWOYnSTuxK69f6lErdNpcoQ+FUjjxdsa6Ln9XtNt4rg1qqaxPAHfIzsQpSL8AzdLJcZoFAeBeA\\\\\\\\\\\\\\\/ee7n8QsTI+oSW5Mgb3\\\\\\\\\\\\\\\/AZQhUavsoPih5nKc4k85O\\\\\\\\\\\\\\\/9Mkg49EFLeB0KKPvuxgoOsOtbKjdN\\\\\\\\\\\\\\\/lrCinH1mW20+EyTLU+ltrKzYQoxWMIXrkyTMF3iC4z8Dg\\\\\\\\\\\\\\\/n1mkJv9Og2ZH5CJngxCovTQlSgfLBt4dpx41cVdV0DgkfKG9z7T4cLJG5dgZoMOCTeDZjkZu0WUYOmvdWtUadLlJDkJ4CmS1MltJkBYaurS\\\\\\\\\\\\\\\/xhnIxcp9QG0rl6ZO9NYGuRKrnYJPBYm4NknZxf0xVPAvNDUfin7uStC2gMEz2M0019wDKjnYgO42wCjES2TCoZnCKn3mBHp1qo8pKxXPR3pMZ8FxSWGXTnf8dFsGwZdO6Bx+wvnmBHatSE\\\\\\\\\\\\\\\/wZWPsPPx4hoiWsV95vT54RExp0iVaD9Tp2uCYpisxrt71BHJjlPKzG6RZPtX6Yz2I0cpuEqnps5By4OfwrU2ok5h3KeQibdOofU4wU6sFfw0Sqdt02b2l\\\\\\\\\\\\\\\/BgMJkTAxG1Gzlx62DYcPTgoXb03ydJT4E4UZrTe34O8LyIjF2PYsTX\\\\\\\\\\\\\\\/llieemB8Ram+aRc0wh1RLzNbeBJV2hsXweF4iOjMlbvQzWLrrMN\\\\\\\\\\\\\\\/J4FujpSZhojHXr85EaLO+haYQWnXUZESf5lOxznhbCK8lUWYYAcNsoOEU9CvajVyBm82ZGT+UUrW4cSz8EZnTC9iGeadgGJT5jkdu+S78fbA85QDi3VeoeFntOiI91QEmK8xwDaZK8eNurKLC1eBD22kb2z\\\\\\\\\\\\\\\/6cDWZZ7LiJhvhU1j+v\\\\\\\\\\\\\\\/ktptFZ3F2Oc4\\\\\\\\\\\\\\\/Ebmqx1XR0UuGMFDwc9hHQ83xIvyBS+uVl6zG7\\\\\\\\\\\\\\\/scR0+zuN9VsCzZcllJgOLlsjOXqQbBs3U8EcXbAba4dM60hlNmDbsaPZAcTBngZnERhIOPkrGsX22jUj7ltiTN5ccglAEyzo\\\\\\\\\\\\\\\/UXMkmv1WD9yy+aoGKO65oPa059xvHgtEw5ti\\\\\\\\\\\\\\\/5bUSYuMYUfrDAO6k7+yGltmiwZbt3Kb3kAOP\\\\\\\\\\\\\\\/etTjbCkZeeg13dmwdvXSJLA1IwvmazuZtIBSQeP2jaSdXBWhTfdbgxfBSH3gxQGd64eeN6+vfPVoXtjRcK9BFTsre9oFRVsv6BINF2rrm4bjIYbt+ynC40O5JtZhrxGpAwdZxJU6ST8eZwgc4sWH6wlAktG0ZIJZMxZre9AbdCwuL4QxSMdlaQqO94NwlqfHaf+gJ\\\\\\\\\\\\\\\/TnQT3ct4XQF3TsKof3RIarNTIgMeXSsOf5Rr3G7Qjn9DGiUtAMiliJuqKgnIuftN0SgZc2zOfCKzQQomaGGflZ1YJUxa12fL1YkZvxO42Q\\\\\\\\\\\\\\\/VTrVJBGCF3is7cPNei+rOnZv8CkTeogEUDkayo435rVeojrhep7MJyFVHMIvSfIiCc89AkryXgr0fqbXuxTeyMG1R7BsgZAzcuFn9OJHrihMkNWaoQM2WUhJzBSixcoscY+ew\\\\\\\\\\\\\\\/yD\\\\\\\\\\\\\\\/kcZUM247VNK9zzHiSnHFJ7uPQda5tRztXxFWNA+bDidJq\\\\\\\\\\\\\\\/6V5wA2aK90sOTLdJ84pONNjReEvr\\\\\\\\\\\\\\\/wnW2Udw+iT8NEJ3e+fvR8DeTuKtKTyYbCWS1R7dA7igYjJnJ+L\\\\\\\\\\\\\\\/l+hSZVYXWloTWOli\\\\\\\\\\\\\\\/KTTQHwAdpdBUp6PRT6F0NFBE\\\\\\\\\\\\\\\/GmntnSWpH3QPHZ0ak3LOaiNm+UAMu5g7GrzQSVD+XqpU6P170AKTkfHu4\\\\\\\\\\\\\\\/E3CT3uRu6USD0uz4HnGidrnmBwaU80lbzlysfRYig\\\\\\\\\\\\\\\/TXpLhvW1EuNq2GbTt7JOWdIK8iVCrxl9raVLveL81ZbEQ\\\\\\\\\\\\\\\/n7bfASZ7wCOaN3uekwJhkSA4BuryJp6pyqHac3iG5KVhjrI3k+5K8U8StfwpOnJZkXwAD5ywdNn4xCnvVbcotVUwU\\\\\\\\\\\\\\\/OTzRzjIdNgUwPtJg9i6AGsys2KFv\\\\\\\\\\\\\\\/VYosd4uWVtkdgY\\\\\\\\\\\\\\\/nBQpVk5O4VHXBMtYU3OFaa00rzGRY88Dj4\\\\\\\\\\\\\\\/uyRK9emDZ2Pp5U8x8P6dtGtr6BQ4C\\\\\\\\\\\\\\\/m\\\\\\\\\\\\\\\/AimIDPconayrPKVYkKp0GGHShQTQZlTRA6MB096FA9D7ATvO4OfDww7DIcfgXFF\\\\\\\\\\\\\\\/3Ca38dQmJP6DdRquNnHyAJJIGB+Ak\\\\\\\\\\\\\\\/fSTaUOve5oxcaWwAHYNaOqxSotRg2fEJV5iKEhAsaRbdkmsBATrabygCYojQg5N2aSBlddPMaFA\\\\\\\\\\\\\\\/v1\\\\\\\\\\\\\\\/koK2bITayhhD3SJLFADB2GC864OMi2xPd8kMoXy50K8PmzhJ546xrtR\\\\\\\\\\\\\\\/Y6DTX0fHu50xjm7+yzeaIDH80d+Tjs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/f62I1c\\\\\\\\\\\\\\\/BXTzOfmykgVyFSJqGqvn1uKvtypP70q4DzSpfiGAfV3NLAzPNidSwMHRIBPrVj8Lm6mBOxhooqiCHxswawHj+Ms\\\\\\\\\\\\\\\/wTA7iB7grv9dVCykA1yyEDez8ELY5QI975pvQMRh2DOo21hlkt9gJdVAs3zoVaq4FHlaK0jLw7auwRHXBu+8gRtpLg==\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GvDX5v834QGnbIaZq8IkMw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022eb346b7e192e548c4b709c54f584b5497b04b17170d924ea6192435ca028fc01\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000313.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000313.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022bmjj\u0022:{\u0022show_corresp\u0022:false},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/content_types\\\/js\\\/bmjj-contributors.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__XqNETqO2KISUuux0IjZeixOTFnSk20iJyWcdyjFvJv0__V5XKdmT7SKbPMZ3oiYeZn3IKAzRNs6WzDcLxN472J6o__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-art-info\u0022\u003E\u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022\u003E\n\t  \u003Cdiv class=\u0022panel-row-wrapper panel-row-first clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022top-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-top\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-crossmark\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003C!-- Start CrossMark Snippet v2.0 --\u003E\n    \u003Ca data-target=\u0022crossmark\u0022 class=\u0022crossmark-square\u0022\u003E\u003Cimg src=\u0022https:\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/logos\/CROSSMARK_Color_square.svg\u0022 alt=\u0022\u0022\u003E\u003C\/a\u003E\n    \u003Cdiv id=\u0022crossmark-dialog\u0022 style=\u0022display: none;\u0022 title=\u0022\u0022\u003E\n    \u003C!-- the external CrossMark data is loaded inside this iframe --\u003E\n    \u003Ciframe id=\u0022crossmark-dialog-frame\u0022\u003E\u003C\/iframe\u003E\n    \u003C\/div\u003E\n    \u003C!-- End CrossMark Snippet --\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-contributors author-ids col-narrow-12\u0022\u003E\n  \n        \u003Ch3 class=\u0022pane-title\u0022\u003EAuthors\u003C\/h3\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-contributors field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul class=\u0022highwire-contributors-list multiple-contrib\u0022\u003E\u003Cli class=\u0022first odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJohn W\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EWalker\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-1\u0022\u003EDepartment of Oncology, Division of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-2\u0022\u003EUniversity of Alberta, Cross Cancer Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EEdmonton\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EAlberta\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003ECanada\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-3006-6145\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Walker%20JW\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJohn%20W%20Walker%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ECeleste\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ELebb\u0026Atilde;\u0026copy;\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-3\u0022\u003EINSERM U976 and Dermatology and CIC, AP-HP, Saint Louis Hospital\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-4\u0022\u003EUniversit\u0026Atilde;\u0026copy; de Paris\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EParis\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EFrance\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Lebb%C3%A9%20C\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ACeleste%20Lebb%C3%A9%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EGiovanni\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EGrignani\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-5\u0022\u003EDivision of Medical Oncology, Candiolo Cancer Institute\u0026acirc;\u0026#128;\u0026#148;FPO, IRCCS, Candiolo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETorino\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Grignani%20G\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AGiovanni%20Grignani%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPaul\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ENathan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-6\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-7\u0022\u003EMount Vernon Cancer Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENorthwood\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EMiddlesex\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Nathan%20P\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APaul%20Nathan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ELuc\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EDirix\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-8\u0022\u003EGZA Ziekenhuizen Campus Sint-Augustinus\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-9\u0022\u003EUniversity of Antwerp\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EAntwerp\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EBelgium\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Dirix%20L\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ALuc%20Dirix%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EEyal\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EFenig\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-10\u0022\u003ESackler Faculty of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-11\u0022\u003ETel Aviv University\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ETel Aviv\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EIsrael\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Fenig%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AEyal%20Fenig%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EPaolo Antonio\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EAscierto\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-12\u0022\u003EMelanoma, Cancer Immunotherapy and Development Therapeutics Unit\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-13\u0022\u003EIstituto Nazionale Tumori IRCCS Fondazione Pascale\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENaples\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EItaly\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022nlm-contrib-id\u0022 data-contrib-id-type=\u0022orcid\u0022 data-authenticated=\u0022false\u0022 data-href=\u0022http:\/\/orcid.org\/0000-0002-8322-475X\u0022\u003E\u003C\/span\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=Ascierto%20PA\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3APaolo%20Antonio%20Ascierto%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EShahneen\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003ESandhu\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-14\u0022\u003EDepartment of Medical Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-15\u0022\u003EPeter MacCallum Cancer Centre\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMelbourne\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EVictoria\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EAustralia\u003C\/span\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-16\u0022\u003ESir Peter MacCallum Department of Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-17\u0022\u003EThe University of Melbourne\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EMelbourne\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EVictoria\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EAustralia\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Sandhu%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AShahneen%20Sandhu%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ERodrigo\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EMunhoz\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-18\u0022\u003EOncology Center\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-19\u0022\u003EHospital S\u0026Atilde;\u0026shy;rio-Liban\u0026Atilde;\u0026ordf;s\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ES\u0026Atilde;\u0026pound;o Paulo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ES\u0026Atilde;\u0026pound;o Paulo\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EBrazil\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Munhoz%20R\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ARodrigo%20Munhoz%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EElena\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EBenincasa\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-20\u0022\u003EMedical Affairs\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-21\u0022\u003EMerck KGaA\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EDarmstadt\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EHessen\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EGermany\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Benincasa%20E\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AElena%20Benincasa%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESarah\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EFlaskett\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-22\u0022\u003ERegional Clinical Operations\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-23\u0022\u003EMerck Serono\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EFeltham\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EMiddlesex\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUK\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Flaskett%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASarah%20Flaskett%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EJosh\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EReed\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-24\u0022\u003EMedical Affairs\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-25\u0022\u003EEMD Serono Research and Development Institute\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EBillerica\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EMassachusetts\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Reed%20J\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AJosh%20Reed%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EArne\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EEngelsberg\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-26\u0022\u003EPfizer Oncology\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-27\u0022\u003EPfizer Pharma\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EBerlin\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EGermany\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Engelsberg%20A\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AArne%20Engelsberg%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022even\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003ESubramanian\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EHariharan\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-28\u0022\u003EMedical Affairs\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-29\u0022\u003EPfizer\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003ENew York\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003ENew York\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EUSA\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Hariharan%20S\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3ASubramanian%20Hariharan%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022last odd\u0022\u003E\u003Cspan class=\u0022nlm-given-names\u0022\u003EVijay\u003C\/span\u003E \u003Cspan class=\u0022nlm-surname\u0022\u003EKasturi\u003C\/span\u003E \u003Cspan class=\u0022nlm-aff\u0022\u003E\n\n\u003Cspan class=\u0022nlm-institution\u0022 data-content-type=\u0022department\u0022 data-hwp-id=\u0022institution-20\u0022\u003EMedical Affairs\u003C\/span\u003E, \u003Cspan class=\u0022nlm-institution\u0022 data-hwp-id=\u0022institution-21\u0022\u003EMerck KGaA\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022city\u0022\u003EDarmstadt\u003C\/span\u003E, \u003Cspan class=\u0022nlm-addr-line\u0022 data-content-type=\u0022state\u0022\u003EHessen\u003C\/span\u003E, \u003Cspan class=\u0022nlm-country\u0022\u003EGermany\u003C\/span\u003E\n\u003C\/span\u003E \u003Ca href=\u0022\/lookup\/external-ref?access_num=Kasturi%20V\u0026amp;link_type=AUTHORSEARCH\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EPubMed articles\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/google-scholar?author%5B0%5D=%22author%3AVijay%20Kasturi%22\u0026amp;gs_type=author\u0022 target=\u0022_blank\u0022 class=\u0022authour-link\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EGoogle scholar articles\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-citation\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECitation\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-article-citation highwire-citation-type-highwire-article node13369\u0022 data-node-nid=\u002213369\u0022 id=\u0022node-13369--21179829044\u0022 data-pisa=\u0022jitc;8\/1\/e000313\u0022 data-pisa-master=\u0022jitc;jitc-2019-000313\u0022 data-apath=\u0022\/jitc\/8\/1\/e000313.atom\u0022\u003E\u003Cdiv class=\u0022highwire-cite highwire-cite-highwire-article highwire-citation-v1-cp clearfix bmjj-article-citation\u0022\u003E\n  \n  \n    \t\u003Cdiv class=\u0022highwire-cite-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-authors\u0022\u003E\u003Cspan class=\u0022highwire-citation-author first\u0022 data-delta=\u00220\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EWalker\u003C\/span\u003E JW\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00221\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003ELebb\u0026Atilde;\u0026copy;\u003C\/span\u003E C\u003C\/span\u003E, \u003Cspan class=\u0022highwire-citation-author\u0022 data-delta=\u00222\u0022\u003E\u003Cspan class=\u0022nlm-surname\u0022\u003EGrignani\u003C\/span\u003E G\u003C\/span\u003E\u003C\/span\u003E\u003Cspan class=\u0022citation-et\u0022\u003E, et al\u003C\/span\u003E\u003C\/div\u003E\n  \n      \u003Cdiv class=\u0022highwire-cite-title\u0022\u003EEfficacy and safety of avelumab treatment in patients with metastatic Merkel cell carcinoma: experience from a global expanded access program\u003C\/div\u003E  \n      \n    \t\u003Cdiv class=\u0022highwire-cite-metadata bmjj-citation-metadata\u0022\u003E\u003Cspan class=\u0022highwire-cite-metadata-journal highwire-cite-metadata\u0022\u003EJournal for ImmunoTherapy of Cancer \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-year highwire-cite-metadata\u0022\u003E2020;\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-volume highwire-cite-metadata\u0022\u003E8:\u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-elocation-id highwire-cite-metadata\u0022\u003Ee000313. \u003C\/span\u003E\u003Cspan class=\u0022highwire-cite-metadata-doi highwire-cite-metadata\u0022\u003E\u003Cspan class=\u0022label\u0022\u003Edoi:\u003C\/span\u003E 10.1136\/jitc-2019-000313 \u003C\/span\u003E\u003C\/div\u003E\n  \n  \n  \n\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-mini pane-jnl-template-bmjj-art-pub-history\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panel-display highwire-1col-stacked-layout\u0022 id=\u0022mini-panel-jnl_template_bmjj_art_pub_history\u0022\u003E\n\t  \n  \u003Cdiv class=\u0022panel-row-wrapper clearfix\u0022\u003E\n\t\t\n\t\t\u003Cdiv class=\u0022content-wrapper\u0022\u003E\n\t\t\t\u003Cdiv class=\u0022panel-panel panel-region-content\u0022\u003E\n\t\t\t  \u003Cdiv class=\u0022inside\u0022\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-pubdate bmjj-pub-date\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-a-epubdate field-type-datetime field-label-inline clearfix\u0022\u003E\u003Cdiv class=\u0022field-label\u0022\u003EOnline issue publication\u0026nbsp;\u003C\/div\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022date-display-single\u0022\u003EJanuary 11, 2022\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content pane-highwire-permission-link\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022 data-pid=\u0022new-d5e9ecaa-460b-40c1-87fb-0dbcbc3a749d\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-copyright\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ECopyright information\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022field field-name-field-highwire-copyright field-type-text field-label-hidden\u0022\u003E\u003Cdiv class=\u0022field-items\u0022\u003E\u003Cdiv class=\u0022field-item even\u0022\u003E\u003Cspan class=\u0022nlm-copyright-statement\u0022 data-hwp-id=\u0022copyright-statement-1\u0022\u003E\u0026Acirc;\u0026copy; Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.\u003C\/span\u003E \u003Cspan class=\u0022nlm-license\u0022 data-license-type=\u0022open-access\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/\u0022 data-hwp-id=\u0022license-1\u0022\u003E\u003Cspan class=\u0022ali-license_ref\u0022 data-start_date=\u00222020-04-08\u0022\u003E\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E\u003C\/span\u003E\u003Cspan class=\u0022nlm-p\u0022 data-hwp-id=\u0022p-1\u0022\u003EThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See \u003Ca class=\u0022nlm-ext-link\u0022 data-l-rel=\u0022related\u0022 data-l-ref-type=\u0022uri\u0022 data-l-ref=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-ext-link-type=\u0022uri\u0022 data-xlink-href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022 data-hwp-id=\u0022ext-link-1\u0022 href=\u0022http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\u003C\/a\u003E.\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n\t\t\t\u003C\/div\u003E\n\t\t\u003C\/div\u003E\n\t\n\t\u003C\/div\u003E \u003C!-- \/.panel-row-wrapper --\u003E\t\n\t\n\t\u003C\/div\u003E\n\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022\/\/crossmark-cdn.crossref.org\/widget\/v2.0\/widget.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}