translational medical research

Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma
Yaya Chu, Gaurav Nayyar, Nang Kham Su, Jeremy M Rosenblum, Patrick Soon-Shiong, John Lee, Jeffrey T Safrit, Matthew Barth, Dean Lee, Mitchell S Cairo

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001238; DOI: 10.1136/jitc-2020-001238
Phase Ib study of anti-CSF-1R antibody emactuzumab in combination with CD40 agonist selicrelumab in advanced solid tumor patients
Jean-Pascal Machiels, Carlos Gomez-Roca, Jean-Marie Michot, Dmitriy Zamarin, Tara Mitchell, Gaetan Catala, Lauriane Eberst, Wolfgang Jacob, Anna-Maria Jegg, Michael A Cannarile, Carl Watson, Galina Babitzki, Konstanty Korski, Irina Klaman, Priscila Teixeira, Sabine Hoves, Carola Ries, Georgina Meneses-Lorente, Francesca Michielin, Randolph Christen, Dominik Rüttinger, Martin Weisser, Jean-Pierre Delord, Philippe Cassier

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001153; DOI: 10.1136/jitc-2020-001153
FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells
Lucia Campos Carrascosa, Adriaan A van Beek, Valeska de Ruiter, Michail Doukas, Jie Wei, Timothy S Fisher, Keith Ching, Wenjing Yang, Karlijn van Loon, Patrick P C Boor, Yannick S Rakké, Lisanne Noordam, Pascal Doornebosch, Dirk Grünhagen, Kees Verhoef, Wojciech G Polak, Jan N M IJzermans, Irene Ni, Yik Andy Yeung, Shahram Salek-Ardakani, Dave Sprengers, Jaap Kwekkeboom

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e000816; DOI: 10.1136/jitc-2020-000816
Rationalizing the pathway to personalized neoadjuvant immunotherapy: the Lombard Street Approach
Judith M Versluis, Daniela S Thommen, Christian U Blank

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e001352; DOI: 10.1136/jitc-2020-001352
Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles
Jacob J Orme, Elizabeth Ann L Enninga, Fabrice Lucien-Matteoni, Heather Dale, Edwin Burgstaler, Susan M Harrington, Matthew K Ball, Aaron S Mansfield, Sean S Park, Mathew S Block, Svetomir N Markovic, Yiyi Yan, Haidong Dong, Roxana S Dronca, Jeffrey L Winters

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e001113; DOI: 10.1136/jitc-2020-001113
An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors
Kirsty Taylor, Helen Loo Yau, Ankur Chakravarthy, Ben Wang, Shu Yi Shen, Ilias Ettayebi, Charles A Ishak, Philippe L Bedard, Albiruni Abdul Razak, Aaron R Hansen, Anna Spreafico, Dave Cescon, Marcus O Butler, Amit M Oza, Stephanie Lheureux, Neda Stjepanovic, Brendan Van As, Sarah Boross-Harmer, Lisa Wang, Trevor J Pugh, Pamela S Ohashi, Lillian L Siu, Daniel D De Carvalho

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000883; DOI: 10.1136/jitc-2020-000883
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19
Riyue Bao, Kyle Hernandez, Lei Huang, Jason John Luke

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e001020; DOI: 10.1136/jitc-2020-001020
Correlates of clinical benefit from immunotherapy and targeted therapy in metastatic renal cell carcinoma: comprehensive genomic and transcriptomic analysis
Nazli Dizman, Yung Lyou, Nicholas Salgia, Paulo Gustavo Bergerot, JoAnn Hsu, Daniel Enriquez, Tyler Izatt, Jeffrey M Trent, Sara Byron, Sumanta Pal

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000953; DOI: 10.1136/jitc-2020-000953

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