Oncolytic virotherapy

Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells
Richard Baugh, Hena Khalique, Emma Page, Janet Lei-Rossmann, Peter Kok-Ting Wan, Timothy Johanssen, Daniel Ebner, Olaf Ansorge, Leonard W Seymour

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008460; DOI: 10.1136/jitc-2023-008460
RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment
Yuan Meng, Haotian Liu, Haoran Zhu, Wanrong Zhang, Dong Sun, Xuefei Han, Ying Liu, Guangzuo Luo

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e007171; DOI: 10.1136/jitc-2023-007171
Oncolytic varicella-zoster virus engineered with ORF8 deletion and armed with drug-controllable interleukin-12
Haifei Jiang, Rebecca Nace, Talia Fernandez Carrasco, Lianwen Zhang, Kah Whye Peng, Stephen J Russell

Journal for ImmunoTherapy of Cancer Mar 2024, 12 (3) e008307; DOI: 10.1136/jitc-2023-008307
Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade
Fei Ju, Yong Luo, Chaolong Lin, Xian Jia, Zilong Xu, Rui Tian, Yanhua Lin, Min Zhao, Yating Chang, Xiaoxuan Huang, Shaopeng Li, Wenfeng Ren, Yaning Qin, Mengqin Yu, Jizong Jia, Jinle Han, Wenxin Luo, Jun Zhang, Guo Fu, Xiangzhong Ye, Chenghao Huang, Ningshao Xia

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004762; DOI: 10.1136/jitc-2022-004762
An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy
Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei

Journal for ImmunoTherapy of Cancer Mar 2024, 12 (3) e008431; DOI: 10.1136/jitc-2023-008431
VB-111 (ofranergene obadenovec) in combination with nivolumab in patients with microsatellite stable colorectal liver metastases: a single center, single arm, phase II trial
Kelley Coffman-D'Annibale, Yuta Myojin, Cecilia Monge, Changqing Xie, Donna Mabry Hrones, Bradford J Wood, Elliot B Levy, David Kleiner, William Douglas Figg, Seth M Steinberg, Bernadette Redd, Tim F Greten

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e008079; DOI: 10.1136/jitc-2023-008079
Development of the oncolytic virus, CF33, and its derivatives for peritoneal-directed treatment of gastric cancer peritoneal metastases
Annie Yang, Zhifang Zhang, Shyambabu Chaurasiya, Anthony K Park, Audrey Jung, Jianming Lu, Sang-In Kim, Saul Priceman, Yuman Fong, Yanghee Woo

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006280; DOI: 10.1136/jitc-2022-006280
Intratumor childhood vaccine-specific CD4⁺ T-cell recall coordinates antitumor CD8⁺ T cells and eosinophils
Michael C Brown, Georgia M Beasley, Zachary P McKay, Yuanfan Yang, Annick Desjardins, Dina M Randazzo, Daniel Landi, David M Ashley, Darell D Bigner, Smita K Nair, Matthias Gromeier

Journal for ImmunoTherapy of Cancer Apr 2023, 11 (4) e006463; DOI: 10.1136/jitc-2022-006463
Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in patients with advanced solid tumors
Charles M Rudin, Hardev S Pandha, Matthew Zibelman, Wallace L Akerley, Kevin J Harrington, Daphne Day, Andrew G Hill, Steven J O'Day, Timothy D Clay, Gavin M Wright, Ross R Jennens, David E Gerber, Jonathan E Rosenberg, Christy Ralph, David C Campbell, Brendan D Curti, Jaime R Merchan, Yixin Ren, Emmett V Schmidt, Lisa Guttman, Sumati Gupta

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005007; DOI: 10.1136/jitc-2022-005007
Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies
Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Mi-Ju Park, Byung-Jin Jung, Yun-Kyoung Hong, Dong-Sup Lee, Keunhee Oh

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e006024; DOI: 10.1136/jitc-2022-006024

Main menu

Oncolytic virotherapy

Pages

Log in using your username and password

Main menu

Log in using your username and password

You are here

Oncolytic virotherapy

Pages