Immunotherapy

Intratumoral administration of CD1c (BDCA-1)⁺ and CD141 (BDCA-3)⁺ myeloid dendritic cells in combination with talimogene laherparepvec in immune checkpoint blockade refractory advanced melanoma patients: a phase I clinical trial
Julia Katharina Schwarze, Jens Tijtgat, Gil Awada, Louise Cras, Angela Vasaturo, Christopher Bagnall, Ramses Forsyth, Inès Dufait, Sandra Tuyaerts, Ivan Van Riet, Bart Neyns

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005141; DOI: 10.1136/jitc-2022-005141
Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis
James L Alexander, Hajir Ibraheim, Camellia Richards, Ben Shum, Polychronis Pavlidis, Nikki Hunter, Julian P Teare, Andrew Wotherspoon, Andrew Furness, Samra Turajlic, Lisa Pickering, James Larkin, Ally Speight, Sophie Papa, Nick Powell

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005490; DOI: 10.1136/jitc-2022-005490
Personalized neoantigen vaccine combined with PD-1 blockade increases CD8⁺ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models
Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu, Honghao Ye, Yang Zhou, Jiahe Ouyang, Zhixiong Cai, Xiaolong Liu

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004389; DOI: 10.1136/jitc-2021-004389
Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model
Jinho Kang, Hye-Jin Lee, Jimin Lee, Jinhwa Hong, Yeul Hong Kim, Mary L Disis, Jeong-An Gim, Kyong Hwa Park

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004702; DOI: 10.1136/jitc-2022-004702
Response of primary tumor and lymph node in non-small cell lung cancer after neoadjuvant immunotherapy: a pooled analysis
Wen-Yu Zhai, Ze-Rui Zhao, Si Chen, Hui Yu, Yao-Bin Lin, Yi-Zhi Wang, Hao Long

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005160; DOI: 10.1136/jitc-2022-005160
Restoration of p53 activity via intracellular protein delivery sensitizes triple negative breast cancer to anti-PD-1 immunotherapy
Zaofeng Yang, Jacquelyne Ka-Li Sun, Marianne M Lee, Michael K Chan

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005068; DOI: 10.1136/jitc-2022-005068
Generation and in vivo validation of an IL-12 fusion protein based on a novel anti-human FAP monoclonal antibody
Lisa Nadal, Frederik Peissert, Abdullah Elsayed, Tobias Weiss, Thomas Look, Michael Weller, Geny Piro, Carmine Carbone, Giampaolo Tortora, Mattia Matasci, Nicholas Favalli, Riccardo Corbellari, Cesare Di Nitto, Eleonora Prodi, Chiara Libbra, Simone Galeazzi, Claudiopietro Carotenuto, Cornelia Halin, Emanuele Puca, Dario Neri, Roberto De Luca

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005282; DOI: 10.1136/jitc-2022-005282
FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer
Jiaxin Liu, Lingyun Wei, Nan Hu, Dong Wang, Juan Ni, Sha Zhang, Hongbing Liu, Tangfeng Lv, Jie Yin, Mingxiang Ye, Yong Song

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005116; DOI: 10.1136/jitc-2022-005116
Extensive plasma proteomic profiling revealed receptor activator of nuclear factor kappa-Β ligand (RANKL) as emerging biomarker of nivolumab clinical benefit in patients with metastatic renal cell carcinoma
Sonia Simonetti, Michele Iuliani, Marco Stellato, Silvia Cavaliere, Bruno Vincenzi, Giuseppe Tonini, Daniele Santini, Francesco Pantano

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005136; DOI: 10.1136/jitc-2022-005136
Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naïve and PD-1 antibody-experienced patients with melanoma (MEL64)
Rick D Vavolizza, Gina R Petroni, Ileana S Mauldin, Kimberly A Chianese-Bullock, Walter C Olson, Kelly T Smith, Lynn T Dengel, Kathleen Haden, William W Grosh, Varinder Kaur, Nikole Varhegyi, Elizabeth M Gaughan, Craig L Slingluff

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005424; DOI: 10.1136/jitc-2022-005424

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