Immunotherapy

Changes in circulating tumor DNA and outcomes in solid tumors treated with immune checkpoint inhibitors: a systematic review
Laith Al-Showbaki, Brooke Wilson, Faris Tamimi, Consolacion Molto, Abhenil Mittal, David W Cescon, Eitan Amir

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005854; DOI: 10.1136/jitc-2022-005854
Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody
Xinyu Song, Anwen Xiong, Fengying Wu, Xuefei Li, Jing Wang, Tao Jiang, Peixin Chen, Xiaoshen Zhang, Zhikai Zhao, Huifang Liu, Lei Cheng, Chao Zhao, Zhehai Wang, Chaohu Pan, Xiaoli Cui, Ting Xu, Haitao Luo, Caicun Zhou

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e006234; DOI: 10.1136/jitc-2022-006234
Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells
Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman, Stephen J Kron

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005862; DOI: 10.1136/jitc-2022-005862
CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden
Jitske van den Bulk, Manon van der Ploeg, Marieke E Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C M J Peeters, Arantza Fariña-Sarasqueta, Els M E Verdegaal, Sjoerd H van der Burg, Thomas Duhen, Noel F C C de Miranda

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005887; DOI: 10.1136/jitc-2022-005887
Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma
Tracy W Liu, Seth T Gammon, Ping Yang, Wencai Ma, Jing Wang, David Piwnica-Worms

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005837; DOI: 10.1136/jitc-2022-005837
TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma
Maximilian O Schaettler, Rupen Desai, Anthony Z Wang, Alexandra J Livingstone, Dale K Kobayashi, Andrew T Coxon, Jay A Bowman-Kirigin, Connor J Liu, Mao Li, Diane E Bender, Michael J White, David M Kranz, Tanner M Johanns, Gavin P Dunn

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e006121; DOI: 10.1136/jitc-2022-006121
Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models
Esther Schoutrop, Thomas Poiret, Ibrahim El-Serafi, Ying Zhao, Rui He, Alina Moter, Johan Henriksson, Moustapha Hassan, Isabelle Magalhaes, Jonas Mattsson

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005691; DOI: 10.1136/jitc-2022-005691
SAFFRON-103: a phase 1b study of the safety and efficacy of sitravatinib combined with tislelizumab in patients with locally advanced or metastatic non-small cell lung cancer
Jun Zhao, Xinmin Yu, Dingzhi Huang, Zhiyong Ma, Bo Gao, Jiuwei Cui, Qian Chu, Qing Zhou, Meili Sun, Daphne Day, Jingxun Wu, Hongming Pan, Lifeng Wang, Mark Voskoboynik, Zhehai Wang, Yunpeng Liu, Hui Li, Juan Zhang, Yanyan Peng, Yi-Long Wu

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e006055; DOI: 10.1136/jitc-2022-006055
Phase 1 first-in-human study of dalutrafusp alfa, an anti–CD73-TGF-β-trap bifunctional antibody, in patients with advanced solid tumors
Anthony W Tolcher, Michael Gordon, Kathleen M Mahoney, Anna Seto, Marianna Zavodovskaya, Chia-Hsiang Hsueh, Shuyan Zhai, Thomas Tarnowski, Juliane M Jürgensmeier, Susanna Stinson, Ahmed A Othman, Tianling Chen, James Strauss

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005267; DOI: 10.1136/jitc-2022-005267
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma
Xiaobin Wang, Qiaoyun Zhang, Jingwen Zhou, Zecong Xiao, Jianxin Liu, Shaohui Deng, Xiaoyang Hong, Wensou Huang, Mingyue Cai, Yongjian Guo, Jingjun Huang, Yong Wang, Liteng Lin, Kangshun Zhu

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e006493; DOI: 10.1136/jitc-2022-006493

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