Immunotherapy

Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response
Elizabeth R Stirling, Masaki Terabe, Adam S Wilson, Mitra Kooshki, Liliya M Yamaleyeva, Martha A Alexander-Miller, Wei Zhang, Lance D Miller, Pierre L Triozzi, David R Soto-Pantoja

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e004712; DOI: 10.1136/jitc-2022-004712
Nivolumab serum concentration in metastatic melanoma patients could be related to outcome and enhanced immune activity: a gene profiling retrospective analysis
Domenico Mallardo, Diana Giannarelli, Maria Grazia Vitale, Domenico Galati, Giusy Trillò, Assunta Esposito, Maria Antonietta Isgrò, Grazia D'Angelo, Lucia Festino, Vito Vanella, Claudia Trojaniello, Andrew White, Teresa De Cristofaro, Michael Bailey, Sandro Pignata, Corrado Caracò, Antonella Petrillo, Paolo Muto, Piera Maiolino, Alfredo Budillon, Sarah Warren, Ernesta Cavalcanti, Paolo Antonio Ascierto

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005132; DOI: 10.1136/jitc-2022-005132
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G Jegga, Yi Zheng, Fukun Guo

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e004806; DOI: 10.1136/jitc-2022-004806
MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2
Mengmeng Jiang, Yang Yang, Liling Niu, Ping Li, Yibo Chen, Ping Liao, Yifei Wang, Jingbin Zheng, Fengyang Chen, Huanhuan He, Hui Li, Xin Chen

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005241; DOI: 10.1136/jitc-2022-005241
Implication of ^99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells
Yu Gao, Qi Luo, Zhichen Sun, Hannan Gao, Yue Yu, Yining Sun, Xiaotu Ma, Chuanhui Han, Jiyun Shi, Fan Wang

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e005925; DOI: 10.1136/jitc-2022-005925
Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
Alex Frias, Luca Di Leo, Asier Antoranz, Loulieta Nazerai, Marco Carretta, Valérie Bodemeyer, Chiara Pagliuca, Christina Dahl, Giuseppina Claps, Giulio Eugenio Mandelli, Madhavi Dipak Andhari, Maria Pires Pacheco, Thomas Sauter, Caroline Robert, Per Guldberg, Daniel Hargbøl Madsen, Francesco Cecconi, Francesca Maria Bosisio, Daniela De Zio

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006389; DOI: 10.1136/jitc-2022-006389
Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: case report and systematic review of the literature
Lisa L Liu, Marcus Skribek, Ulrika Harmenberg, Marco Gerling

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e005841; DOI: 10.1136/jitc-2022-005841
Systemic inflammation shapes clinical outcomes in response to immune checkpoint blockade treatment: moving toward optimizing antitumor immunity
Ming Zheng

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006462; DOI: 10.1136/jitc-2022-006462
Efficacy and toxicity of adjuvant radiotherapy in recurrent melanoma after adjuvant immunotherapy
Prachi Bhave, Angela Hong, Serigne N Lo, Rebecca Johnson, Johanna Mangana, Douglas B Johnson, Ozgecan Dulgar, Zeynep Eroglu, Hui-Ling Yeoh, Andrew Haydon, Georg C Lodde, Elisabeth Livingstone, Adnan Khattak, Katharina Kähler, Axel Hausschild, Grant A McArthur, Alexander Maxwell Menzies, Georgina Long, Wei Wang, Matteo S Carlino

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006629; DOI: 10.1136/jitc-2022-006629
Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor
Takahiro Arai, Tomomi Kokubo, Ruiheng Tang, Hirohito Abo, Ayu Terui, Jotaro Hirakawa, Hidetaka Akita, Hiroto Kawashima, Akihiro Hisaka, Hiroto Hatakeyama

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005657; DOI: 10.1136/jitc-2022-005657

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