Patient numbers by max CD ranges (nuclei/square millimeter) and WHO gradea
| Cellular Density Cutoff Ranges | WHO IIMedian OS: NA95% CI, 4040 to NA | WHO IIIMedian OS: 5066 95% CI, 3486 to NA | WHO IVMedian OS: 49595% CI, 463–538 |
|---|---|---|---|
| CD, <7443Median OS: NA95% CI, 4444 to NA | 65 | 69 | 13 |
| 7443 < CD < 8358Median OS: 373895% CI, 2452 to NA | 84 | 80 | 35 |
| 8358 < CDMedian OS: 60395% CI, 535–658 | 57 | 97 | 679 |
Note:—NA indicates not achieved; OS, overall survival.
↵a The cutoff values for CD were calibrated to separate WHO IV cases from WHO II and III cases and WHO II and III cases from each other using ROC analysis. The off-diagonal values in this matrix speak to the nonredundancy of information captured by CD and WHO grading, respectively.