Patient characteristics
| Unmatched Cohort | Matched Cohort | |||||
|---|---|---|---|---|---|---|
| Near-Occlusion (n = 84 Patients) | Control Group (n = 460 Patients) | P Value | Near-Occlusion (n = 84 Patients) | Control Group (n = 168 Patients) | P Value | |
| Age (mean) (yr) | 70.3 (SD, 9.7) | 68.6 (SD, 8.3) | .091 | 70.3 (SD, 9.7) | 70.2 (SD, 7.7) | .943 |
| Men | 68% | 65% | .620 | 68% | 64% | .576 |
| Current smokers | 43% | 40% | .629 | 43% | 37% | .411 |
| Arterial hypertension | 88% | 88% | 1.000 | 88% | 88% | 1.000 |
| Total plasma cholesterol level (mean) (mmol/L) | 4.4 (SD, 1.1) | 4.2 (SD, 1.0) | .126 | 4.4 (SD, 1.1) | 4.4 (SD, 1.1) | .664 |
| LDL cholesterol level (mean) (mmol/L) | 2.6 (SD, 0.9) | 2.4 (SD, 0.8) | .171 | 2.6 (SD, 0.9) | 2.5 (SD, 0.9) | .629 |
| HDL cholesterol level (mean) (mmol/L) | 1.06 (SD, 0.31) | 1.09 (SD, 0.33) | .695 | 1.06 (SD, 0.31) | 1.09 (SD, 0.33) | .659 |
| Plasma triglyceride level (mean) (mmol/L) | 1.93 (SD, 1.2) | 1.8 (SD, 1.1) | .638 | 1.93 (SD, 1.2) | 1.78 (SD, 1.0) | .614 |
| CRP level (median) (IQR) (mg/L) | 3.6 (1.1–8.6) | 2.3 (0.8–5.5) | .008 | 3.6 (1.1–8.6) | 2.1 (0.9–4.9) | .010 |
| Body mass index (mean) | 28.6 (SD, 4.8) | 28.1 (SD, 4.4) | .483 | 28.6 (SD, 4.8) | 28.0 (SD, 4.1) | .540 |
| Diabetes | 33% | 42% | .184 | 33% | 37% | .676 |
| Chronic kidney disease | 27% | 22% | .324 | 27% | 24% | .644 |
| Chronic bronchopulmonary disease | 14% | 13% | .723 | 14% | 15% | 1.000 |
| Peripheral arterial disease | 32% | 39% | .271 | 32% | 33% | .888 |
| Heart failure with reduced ejection fraction | 15% | 11% | .320 | 15% | 11% | .374 |
| Previous coronary artery bypass | 20% | 18% | .649 | 20% | 17% | .490 |
| Need for heart surgery within 30 days | 5% | 9% | .281 | 5% | 10% | .224 |
| Previous myocardial infarction | 24% | 28% | .506 | 24% | 30% | .302 |
| Previous percutaneous coronary artery intervention | 23% | 32% | .094 | 23% | 24% | .876 |
| Known multivessel coronary artery disease | 39% | 40% | 1.000 | 39% | 35% | .490 |
| Previous stroke | 37% | 30% | .252 | 37% | 40% | .683 |
| Ipsilateral cerebral ischemic symptoms in the past month | 37% | 21% | .003 | 37% | 33% | .577 |
| Ipsilateral cerebral ischemic symptoms in the past 6 months (ie, symptomatic stenosis) | 45% | 29% | .005 | 45% | 46% | .894 |
| Patients with ≥1 risk factors for endarterectomya | 82% | 80% | .766 | 82% | 82% | 1.000 |
Note:—IQR indicates interquartile range; CRP, C-reactive protein.
↵a One of the following: left ventricle ejection fraction of ≤40%, chronic bronchopulmonary disease, prior myocardial infarction, coronary artery bypass grafts, or age 75 years or older.