Recommended imaging sequences for baseline imaging and ARIA monitoring examinations based on clinical trial experience and current guidelinesa
| Minimal | Recommended | Notes | |
|---|---|---|---|
| Field strength | 1.5T | 3T | Use of a consistent field strength for serial imaging of a given patient is important; imaging may be performed at 1.5T if a patient is not a candidate for imaging at 3T or 3T scanners are not available at a site |
| ARIA-E detection | 2D-FLAIR | 2D- or 3D-FLAIR | Either 2D or 3D is acceptable, whichever can be performed with consistent quality and optimal CSF suppression |
| ARIA-H detection | T2*-GRE | T2*-GRE (±SWI) | Recommendations for enrollment and dose suspension are based on T2*-GRE detection of blood products; SWI may also be performed for confirmation and may be of value to gather data going forward |
| Infarct assessment | DWI | DWI | DWI required to differentiate ARIA from acute/subsacute infarct and identification of incidental infarcts |
↵a Additional optional sequences may be added per individual site preference.