Proposed spectrum of opioid syndromes

Clinical DataImaging Findings
CHANTERDecreased level of consciousness in adults, cerebellar edema leading to obstructive hydrocephalus, mixed prognosisCerebellar edema with hippocampal and basal ganglia involvement on DWI
POUNCEDecreased level of consciousness in children, cerebellar edema leading to obstructive hydrocephalus, poor prognosisCerebellar edema without hippocampal and basal ganglia involvement on DWI, more WM involvement with T2 hyperintensity
OAANew-onset amnesia, mild prognosisSymmetric diffusion restriction and FLAIR hyperintensity of the hippocampi