Demographic and clinical data^{^a}

	ALS	Fast	Slow	HC	P Value
Number	29	13	16	24	–
Age (yr)	54.3 (10.2)	56 (9.9)	52.9 (10.6)	51 (10.7)	.244^{^b}^,^{^c}
					.152^{^b}^,^{^d}
					.586^{^b}^,^{^e}
					.388^{^b}^,^{^f}
Sex	9F/20M	6F/7M	3F/13M	11F/13M	.394^{^g}^,^{^c}
					.101^{^g}^,^{^d}
					1.000^{^g}^,^{^e}
					.172^{^g}^,^{^f}
Disease duration (mo)	18.8 (14.5)	19.4 (13.9)	18.4 (15.4)	–	–^{^c},–^{^d},–^{^e} .660^{^h}^,^{^f}
Site of onset
Spinal	22 (6 UL, 16 LL)	10 (3 UL, 7 LL)	12 (3 UL, 9 LL)	–	–
Bulbar	7	3	4	–	–
Revised El Escorial criteria
Definite	7	7	0	–	–
Probable	7	3	6	–	–
Probable laboratory
Supported	6	1	5	–	–
Possible	9	2	5	–	–
Disease progression rate	0.84 (0.87)	1.54 (0.93)	0.27 (0.09)	–	–^{^c},–^{^d},–^{^e} .001^{^h}^,^{^f}
ALSFRS-R (/48)	38.72 (5.55)	37.31 (4.81)	40.46 (6.09)	–	–^{^c},–^{^d},–^{^e} .067^{^h}^,^{^f}

Note:—F indicates female; Fast, fast progressors; LL, lower limb; M, male; mo, month; yr, year; Slow, slow progressors; –, not applicable; UL, upper limb.
↵a Values are expressed as mean (SD), unless otherwise indicated.
↵b Student t test.
↵c ALS versus HC.
↵d Fast versus HC.
↵e Slow versus HC.
↵f Fast versus slow.
↵^gχ² test.
↵h Kruskal-Wallis test.