Association of MR imaging markers of cerebrovascular disease and the presence of microinfarcts in the deep gray matter on 7T MR imaginga
| Patients with Microinfarcts in the Deep Gray Matter (n = 28) | Patients without Microinfarcts in the Deep Gray Matter (n = 185) | All Patients (n = 213) | Microinfarct (Presence vs Absence) RR (95% CI)b | |
|---|---|---|---|---|
| Infarcts on 1.5T MR imaging (%) | ||||
| Cortical | 21 | 11 | 12 | 1.64 (0.76–3.51) |
| Cerebellar | 32 | 9 | 12 | 2.18 (1.23–3.87)c |
| Brainstem | 7 | 1 | 2 | 3.37 (0.95–12.0) |
| Lacunes in the white matter on 1.5T MR imaging (%) | 32 | 6 | 9 | 3.28 (1.79–6.04)c |
| Lacunes in the deep gray matter on 1.5T MR imaging (%) | 43 | 8 | 12 | 3.93 (1.99–7.78)c |
| WMH volumes on 1.5T MR imaging (mL)d | ||||
| Total | 3.3 (0.9–32.5) | 2.0 (0.3–9.3) | 2.0 (0.4–10.0) | 1.13 (0.93–1.38)e |
| Periventricular | 2.9 (0.7–31.7) | 1.4 (0.2–8.3) | 1.4 (0.3–9.0) | 1.14 (0.95–1.37)e |
| Deep | 0.2 (0.1–0.9) | 0.3 (0.0–1.5) | 0.2 (0.0–1.4) | 0.67 (0.38–1.16)e |
| Total brain volume (mL) | 1104.9 (SD, 116.5) | 1125.3 (SD, 104.3) | 1122.7 (SD, 105.9) | 0.84 (0.56–2.72)f |
| Total intracranial volume (mL) | 1449.2 (SD, 114.7) | 1452.6 (SD, 126.4) | 1452.16 (SD, 128.5) | 1.21 (0.85–1.73) |
| Parenchymal CBF (mL/min per 100- mL brain volume) | 50.5 (SD, 16.8) | 48.2 (SD, 12.0) | 48.5 (SD, 12.7) | 1.13 (0.93–1.38) |
| Cortical microinfarcts on 7T MR imaging (%) | 32 | 9 | 12 | 2.33 (1.32–4.13)c |
| Deep microbleeds on 7T MR imaging (%) | 21 | 10 | 12 | 1.60 (0.70–3.68) |
| Lobar microbleeds on 7T MR imaging (%) | 36 | 26 | 27 | 1.27 (0.59–2.72) |
↵a Characteristics are presented as mean (SD) or percentage. RR represents the relative risk for microinfarcts in the presence of an MR imaging marker (in case of a dichotomous variable) or for 1 SD increase in the MR imaging marker (in case of a continuous variable).
↵b Log-binomial regression with adjustment for age.
↵c P < .05.
↵d Median (10th percentile, 90th percentile).
↵e Natural log-transformed due to a non-normal distribution and normalized for total intracranial volume.
↵f Adjusted for age and total intracranial volume.