Table 3:

Microstructure metrics and fiber statistics of focal WM lesions and whole-brain WM^{^a}

	WM Lesion ROIs			Whole-Brain WM
	MS	HC	P Value^{^b}	MS	HC	P Value^{^b}
DTI
FA	0.35 (SD, 0.06)	0.41 (SD, 0.06)	.010	0.39 (SD, 0.02)	0.41 (SD, 0.01)	.655
MD	0.92 (SD, 0.17)	0.74 (SD, 0.04)	<.001	0.76 (SD, 0.06)	0.74 (SD, 0.03)	.334
AD	1.28 (SD, 0.21)	1.08 (SD, 0.04)	.002	1.28 (SD, 0.03)	1.07 (SD, 0.03)	.327
RD	0.77 (SD, 0.15)	0.57 (SD, 0.06)	<.001	0.59 (SD, 0.03)	0.56 (SD, 0.02)	.555
NODDI
f_icvf	0.55 (SD, 0.12)	0.69 (SD, 0.05)	.001	0.69 (SD, 0.06)	0.71 (SD, 0.05)	.914
ODI	0.30 (SD, 0.07)	0.34 (SD, 0.05)	.109	0.34 (SD, 0.02)	0.33 (SD, 0.02)	.334
Fiber
No.	6308 (1319, 11,641)	7582 (1204, 13,494)	.780	199,230 (SD, 46,819)	208,260 (SD, 60,599)	.905
Length	35.11 (SD, 12.21)	39.73 (SD, 8.32)	.211	22.39 (SD, 6.24)	22.73 (SD, 7.21)	.846

↵a Data are mean (SD) except for the number of fibers through lesion areas, which are median (range).
↵b False discovery rate–corrected P values.