Characteristics of all included patients and patients stratified by rFTD grade
| Characteristic | Total | Grade 0 | Grade 1 | Grade 2 | Grade 3 | P |
|---|---|---|---|---|---|---|
| Patients, n | 138 | 14 | 78 | 33 | 13 | |
| Age, (median) (IQR) (yr) | 69 (59, 76) | 63.5 (55.25, 72.75) | 66 (57, 75) | 71 (59, 76.5) | 75 (64, 79) | .169 |
| Males, n (%) | 86 (62.3) | 7 (50) | 48 (61.5) | 21 (63.6) | 10 (76.9) | .546 |
| Clinical characteristics | ||||||
| Onset-to-CT time (median) (IQR) (min) | 119 (63, 201) | 115.5 (70.25, 161.75) | 120 (71.5, 224) | 105 (52.75, 203) | 123 (48.5, 174) | .845 |
| Hypertension, n (%) | 90 (65.9) | 9 (64.3) | 49 (62.8) | 23 (69.7) | 10 (76.9) | .738 |
| Diabetes, n (%) | 45 (32.6) | 6 (42.9) | 18 (23.1) | 15 (45.5) | 6 (46.2) | .059 |
| Smoking, n (%) | 53 (38.4) | 6 (42.9) | 30 (38.5) | 11 (33.3) | 6 (46.2) | .848 |
| Previous stroke and/or TIA, n (%) | 26 (18.8) | 2 (14.3) | 13 (16.7) | 5 (15.2) | 6 (46.2) | .07 |
| Atrial fibrillation, n (%) | 54 (39.1) | 5 (35.7) | 28 (35.9) | 14 (42.4) | 7 (53.8) | .627 |
| Dyslipidemia, n (%) | 24 (17.4) | 2 (14.3) | 14 (17.9) | 6 (18.2) | 2 (15.4) | .984 |
| SBP (median) (IQR) (mm Hg) | 147 (130, 162) | 137 (124.5, 166.5) | 145 (134.5, 160) | 158 (128.5, 169.75) | 147 (131, 172.5) | .508 |
| DBP (median) (IQR) (mm Hg) | 83 (80, 91) | 82.5 (82.25, 89.5) | 85 (80, 91.5) | 85.5 (79.25, 99.75) | 80 (69, 90.5) | .276 |
| ABG (median) (IQR) (mol/L) | 7.4 (6.1, 9.6) | 7.15 (6.33, 8.89) | 7 (5.7, 8.69) | 8.05 (6.29, 10.2) | 7.9 (7.2, 9.45) | .206 |
| Baseline NIHSS score (median) (IQR) | 16 (11, 19) | 10.5 (4.75, 18.5) | 14 (9, 17) | 17.5 (12, 20) | 19 (16.5, 22) | <.001 |
| Occluded site, n (%) | .067 | |||||
| MCA | 87 (63) | 10 (71.4) | 50 (64.1) | 21 (63.6) | 6 (46.2) | |
| ICA | 44 (32.1) | 3 (21.4) | 25 (32.1) | 12 (36.4) | 4 (30.8) | |
| MCA + ICA | 7 (5.1) | 1 (7.1) | 3 (3.8) | 0 (0) | 3 (23.1) | |
| Perfusion parameters | ||||||
| Core (median) (IQR) (mL) | 30.5 (10, 87, 61.25) | 7.35 (0.13, 15.6) | 23.3 (8.65, 43.8) | 45.75 (25.17, 90.25) | 135 (77.85, 185.5) | <.001 |
| Penumbra (median) (IQR) (mL) | 88.3 (52.75, 138.7) | 47.65 (5, 113.37) | 90 (54, 136) | 110.05 (62.42, 155.02) | 92 (50, 167.45) | .043 |
| Low perfusion (median) (IQR) (mL) | 132.3 (83.32, 213.25) | 55.55 (14.5, 116.55) | 121.6 (80.5, 195.5) | 186.55 (141.55, 216.15) | 242 (154, 309.85) | <.001 |
| Mismatch ratioa (median) (IQR) | 3.9 (2.4, 7.1) | 5 (3.22, 21.85) | 5.45 (2.24, 8.42) | 2.6 (1.74, 7.5) | 1.8 (1.4, 2.44) | <.001 |
| TMM, n (%) | 99 (71.7) | 9 (64.3) | 70 (89.7) | 18 (54.5) | 2 (15.4) | <.001 |
| ICV <70 mL, n (%) | 108 (78.3) | 14 (100) | 71 (91) | 20 (60.6) | 3 (23.1) | <.001 |
| ICV <51 mL, n (%) | 93 (67.4) | 13 (92.9) | 62 (79.5) | 18 (54.5) | 0 (0) | <.001 |
Note:—SBP indicates systolic blood pressure; DBP, diastolic blood pressure; ABG, admission blood glucose.
↵a Calculated by low perfusion volume to infarct core volume.