Table 4:

Correlation between individual biomarkers and spondylodiscitis as proved on pathology and/or microbiology^{^a}

	Positive Pathology and/or Microbiology
	r	P	PPV	NPV	Sensitivity	Specificity
Epidural enhancement
Observer 1	0.37	.00^{^b}	61.3	75.6	65.5	72.1
Observer 2	0.42	.001^{^b}	50.9	100	100	34.9
Observer 3	0.39	.001^{^b}	49.2	100	100	30.2
Majority consensus	0.47	.001^{^b}	53.7	100	100	41.9
Paraspinal enhancement
Observer 1	0.34	.03^{^b}	50.0	88.9	93.1	37.2
Observer 2	0.27	.02^{^b}	44.6	100	100	16.3
Observer 3	0.30	.01^{^b}	53.8	75.8	72.4	58.1
Majority consensus	0.39	.01^{^b}	49.2	100	100	30.2
Hyperintense T2 disc signal
Observer 1	0.30	.03^{^b}	49.2	79.6	82.5	42.6
Observer 2	0.15	.05^{^b}	31.2	96.2	95.3	19.6
Observer 3	0.25	.02^{^b}	45.5	80.2	74.2	50.4
Majority consensus	0.28	.03^{^b}	48.0	95.2	93.5	29.8
Vertebral endplate erosion
Observer 1	0.29	.02^{^b}	48.9	82.4	89.6	33.6
Observer 2	0.17	.03^{^b}	37.5	95.8	92.5	27.5
Observer 3	0.33	.01^{^b}	38.1	82.5	76.3	59.1
Majority consensus	0.31	.02^{^b}	42.6	91.5	91.8	34.7
Blood culture growth	0.03	.79	50	59.4	3.4	97.6
Fever status	0.25	.03^{^a}	55.2	69.8	55.2	69.8
Leukocytosis	0.039	.77	40	55.4	13.8	83.8
Hemoglobin count^{^c}	−0.02	.86	NA	NA	NA	NA
Platelet count^{^c}	0.17	.18	NA	NA	NA	NA
ALP level^{^c}	0.05	.73	NA	NA	NA	NA
ESR^{^c}	−0.07	.62	NA	NA	NA	NA
CRP^{^c}	0.26	.04^{^a}	NA	NA	NA	NA