Table 2:

Values of global gray matter network properties between HC and patients with MS and within the MS sample based on cognitive statusa

Network Properties (Mean) (SD)HCMS
Total SampleMS-CPMS-CI
No.18805525
Size6950.17 (700.80)6677.81 (589.84)6607.64 (575.60)6832.20 (603.02)
Degree1234.59 (129.73)1064.42 (124.89)b1080.08 (113.24)1029.97 (143.86)
Density (%)17.77 (0.77)15.97 (1.59)16.37 (1.31)15.10 (1.82)
Clustering0.439 (0.013)0.396 (0.034)0.405 (0.027)0.377 (0.040)
Betweenness5998.11 (609.99)5816.27 (534.55)5741.29 (513.53)5981.22 (553.17)
Path length1.863 (0.009)1.871 (0.014)b1.869 (0.012)1.875 (0.016)
γ1.086 (0.003)1.081 (0.005)1.081 (0.004)1.079 (0.006)
λ1.021 (0.003)1.015 (0.004)b1.016 (0.003)1.012 (0.004)c
Small world1.064 (0.003)1.065 (0.004)1.064 (0.004)1.067 (0.005)
  • a HC versus MS group was statistically compared taking into account sex, education, and global gray matter volume; and the MS-CP versus MS-CI groups were compared with 2 additional confounding factors of T1 and T2 lesion loads (log). Data are corrected for multiple comparisons.

  • b Adjusted P < .05 (comparison of total sample of MS patients with healthy control).

  • c Adjusted P < .01 (comparison within MS group based on cognitive impairment status).