Table 3:

[¹⁸F] FDG-PET/CT characteristics and selected texture parameters differentiating lymph node characterization in patients with head and neck squamous cell carcinoma without HIV infection (group 3 vs 4)

Texture Parameter	Benign Nodes (n = 39)		Malignant Nodes (n = 22)		P Value^{^a}	Cutoff	AUC^{^b} (GLIMMROC)
Texture Parameter	Mean	SD	Mean	SD	P Value^{^a}	Cutoff	AUC^{^b} (GLIMMROC)
Node characteristics
Size (cm)	1.439	0.048	1.687	0.831	.079	DNC	0.643
Volume (cm³)	1.122	0.147	3.468	4.718	.001^{^c}	>2.599	0.702
SUVmax	3.228	0.315	6.438	4.811	.007^{^c}	>3.980	0.731
Histogram
Mean	670.6	68.4	751.8	137.3	.022^{^c}	>738.1	0.705
Geometric mean	225.9	50.6	297.6	124.5	.020^{^c}	>257.5	0.667
Harmonic mean	24.12	4.21	29.57	9.42	.020^{^c}	>25.5	0.678
IQR	1064.3	63.9	865.0	360.2	.022^{^c}	<1017.0	0.723
Fourth moment	8.71E+10	5.74E+09	9.41E+10	1.00E+10	.018^{^c}	>9.38E+10	0.698
GLCM
Contrast	102.5	18.2	81.8	28.3	.015^{^c}	<75.7	0.754
Energy	0.041	0.022	0.072	0.055	.034^{^c}	>0.058	0.712
Homogeneity	0.475	0.056	0.541	0.104	.029^{^c}	>0.528	0.735
GLRL
SRE	0.164	0.011	0.154	0.019	.036^{^c}	<0.153	0.695
RLN	0.183	0.014	0.170	0.023	.034^{^c}	<0.172	0.698
RHGE	254.2	77.2	367.0	193.6	.016^{^c}	>305.4	0.739
LRLGE	322.6	91.4	469.8	231.9	.006^{^c}	>397.1	0.759
LRHGE	246.2	60.5	352.7	168.8	.003^{^c}	>340.9	0.760^{^d}
Laws features
L1	1,130,272.9	280,670.9	876,676.6	413,942.2	.024^{^c}	<911,080.5	0.722

Note:—DNC indicates did not converge; IQR, interquartile range; GLIMMROC, generalized linear mixed model receiver operating characteristic.
↵a Indicates a significant difference by the mixed linear regression model (Proc MIXED) to adjust the variance-covariance matrix among multiple values recorded for each patient (P < .05).
↵b Using the generalized linear mixed model (GLIMMROC).
↵c Significant.
↵d The highest AUC among 41 texture features.