Correlations between lesion and volumetric MRI measures of WM and GM with clinical and neuropsychological variables (age-adjusted linear mixed-effect model with random intercept for recruitment site, false discovery rate–corrected)a
| MRI Measure | Global Cognitive Z Score | Attention Z Score | Visual Memory Z Score | Executive Functions (WCSTpr) | EDSS |
|---|---|---|---|---|---|
| T2 LV | −0.35 (.01) | −0.33 (.008) | −0.34 (.03) | −0.25 (.06) | NS |
| T1 LV | −0.31 (.02) | −0.31 (.01) | −0.33 (.03) | −0.28 (.05) | NS |
| NBV | 0.44 (.01) | 0.44 (.001) | 0.35 (.03) | NS | −0.33 (.01) |
| NGMV | 0.36 (.01) | 0.31 (.01) | NS | NS | NS |
| NCGMV | 0.42 (.01) | 0.36 (.01) | NS | NS | NS |
| NWMV | 0.37 (.01) | 0.40 (.004) | 0.35 (.03) | NS | −0.35 (.008) |
| Total normalized deep GM volume | 0.40 (.001) | 0.47 (<.001) | 0.33 (.04) | NS | −0.29 (.03) |
| Average normalized thalamus volume | 0.36 (.002) | 0.41 (.0005) | 0.30 (.05) | NS | NS |
| Average normalized caudate volume | 0.40 (.001) | 0.50 (<.001) | NS | NS | NS |
| Average normalized putamen volume | 0.40 (.001) | 0.46 (.0001) | 0.37 (.03) | NS | −0.30 (.03) |
| Average normalized pallidum volume | 0.25 (.03) | 0.34 (.003) | NS | NS | −0.35 (.01) |
| Average normalized hippocampus volume | 0.39 (.001) | 0.34 (.003) | NS | NS | NS |
| Average normalized amygdala volume | 0.33 (.01) | 0.33 (.01) | NS | NS | NS |
| Average normalized accumbens volume | 0.32 (.009) | 0.36 (.003) | NS | NS | NS |
Note:—NS indicates not significant; WCSTpr, Wisconsin Card Sorting Test, number of perseverative responses; NBV, normalized brain volume; NGMV, normalized GM volume; NCGMV, normalized cortical GM volume; NWMV, normalized WM volume.
↵a Correlations are reported as standardized coefficients (to include size effect), and P values are reported in parentheses.