Relationship between dual-energy CT/MR imaging and histopathologic findings for the detection of cartilage invasiona
| TP | TN | FN | FP | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|---|---|---|
| Thyroid cartilage (n = 55) | ||||||||
| MRI | 19 | 23 | 0 | 13 | 100 (82–100) | 64 (46–79) | 59 (41–76) | 100 (85–100) |
| Dual-energy CT | 17 | 36 | 2 | 0 | 89 (67–99) | 100 (90–100) | 100 (80–100) | 95 (82–99) |
| P valueb | .5 | <.001 | ||||||
| Cricoid cartilage (n = 55) | ||||||||
| MRI | 8 | 41 | 0 | 6 | 100 (63–100) | 87 (74–95) | 57 (29–82) | 100 (91–100) |
| Dual-energy CT | 6 | 46 | 2 | 1 | 75 (35–97) | 98 (89–100) | 86 (42–100) | 96 (86–99) |
| P valueb | .5 | .06 | ||||||
| Arytenoid cartilage (n = 110) | ||||||||
| MRI | 8 | 91 | 1 | 10 | 89 (52–100) | 91 (83–95) | 44 (22–69) | 99 (94–100) |
| Dual-energy CT | 6 | 98 | 3 | 3 | 67 (30–93) | 97 (92–100) | 67 (30–93) | 97 (92–99) |
| P valuec | .43 | .09 | ||||||
| All cartilage (n = 220) | ||||||||
| MRI | 35 | 155 | 1 | 29 | 97 (85–100) | 84 (78–89) | 55 (42–67) | 99 (96–100) |
| Dual-energy CT | 29 | 180 | 7 | 4 | 81 (64–92) | 98 (95–99) | 88 (72–97) | 96 (92–98) |
| P valuec | .16 | <.004 |
Note:—TP indicates true positive; TN, true negative; FP, false positive; FN, false negative; PPV, positive predictive value; NPV, negative predictive value.
↵a Numbers in parentheses are 95% confidence intervals. Negative findings for cartilage invasion are scores 1 and 2; positive findings are scores 3–5.
↵b As determined with the McNemar test.
↵c According to the generalized linear mixed model that accounted for the multiple observations within patients.