Correlations between quantitative imaging measures in the subcortical GM structures and clinical variables in patients with MSa
| Basal Ganglia Variable | Clinical Variable | ||||||
|---|---|---|---|---|---|---|---|
| Age | Disease Duration | EDSS Score | MSFC Score | 25FTW Score | 9HPT Score | PASAT3 Score | |
| MPF (CN) | −0.42b | −0.34 | −0.52c | 0.39b | −0.29 | −0.40b | 0.34 |
| MPF (GP) | −0.41b | −0.26 | −0.56c | 0.47c | −0.42b | −0.51c | 0.40b |
| MPF (putamen) | −0.30 | −0.53c | −0.52c | 0.57c | −0.49c | −0.60c | 0.44b |
| MPF (SN) | −0.47c | −0.40b | −0.55c | 0.53c | −0.36 | −0.59c | 0.48c |
| MPF (thalamus) | −0.44b | −0.37b | −0.54c | 0.48c | −0.34 | −0.52c | 0.32 |
| T2* (CN) | −0.24 | −0.25 | −0.14 | 0.15 | −0.16 | −0.19 | 0.13 |
| T2* (GP) | −0.19 | −0.15 | −0.33 | 0.17 | −0.16 | −0.23 | 0.25 |
| T2* (putamen) | −0.37b | −0.41b | −0.43b | 0.27 | −0.41b | −0.29 | 0.14 |
| T2* (SN) | −0.04 | 0.14 | −0.16 | −0.24 | −0.02 | 0.24 | −0.25 |
| T2* (thalamus) | −0.11 | −0.02 | −0.23 | −0.05 | −0.09 | 0.05 | −0.04 |
Note:—25FTW indicates the 25-Foot Timed Walk Test; 9HPT, 9-Hole Peg Test; MSFC, Multiple Sclerosis Functional Composite.
↵a Data are Pearson correlation coefficients. To correct for deviations from normal distribution, we applied the Box-Cox transformation to the 25FTW and 9HPT scores with the power of −0.5.
↵b .01 ≤ P < .05.
↵c P <.01.