Comparison of perfusion and volumetric data for cGM, NAWM, and T2h-l between HCs and subjects with RRMS and SPMS after adjusting for confounding factorsa
| Parameter | Median (Interquartiles) | P Value | ||||
|---|---|---|---|---|---|---|
| HC (n = 19) | RRMS (n = 19) | SPMS (n = 20) | RRMS vs HC | SPMS vs HC | SPMS vs RRMS | |
| cGM | ||||||
| Global volume | 890 (869–914) | 864 (827–895) | 673 (646–697) | .10 | .0026b | .0020b |
| CBF | 43.20 (33.91–54.49) | 41.07 (29.85–55.68) | 34.05 (27.19–43.68) | <.0001b | <.0001b | .0011b |
| CBV | 2.64 (2.02–3.29) | 2.53 (1.94–3.37) | 2.40 (1.92–3.07) | .078 | .046 | .0062b |
| MTT | 3.77 (3.20–4.31) | 3.90 (3.32–4.41) | 4.30 (3.66–4.99) | .0001b | <.0001b | <.0001b |
| NAWM | ||||||
| Global volume | 878 (812–894) | 818 (738–850) | 697 (669–729) | .0115b | .0011b | .0049b |
| CBF | 23.49 (18.69–27.78) | 21.55 (16.05–29.50) | 19.54 (16.74–24.92) | .68 | .58 | .0080b |
| CBV | 1.59 (1.28–2.00) | 1.57 (1.17–2.15) | 1.51 (1.30–1.98) | .89 | .16 | .0103b |
| MTT | 4.51 (4.09–5.10) | 4.62 (4.08–5.20) | 4.86 (4.28–5.41) | .25 | .0005b | .0094b |
| T2h-l | ||||||
| Global volume | 0.00 | 5.4 (1.2–9.3) | 6.4 (1.0–10.9) | NA | NA | .82 |
| CBF | 0.00 | 12.77 (8.23–17.24) | 11.15 (8.95–15.71) | NA | NA | .049 |
| CBV | 0.00 | 0.99 (0–1.32) | 1.08 (0.83–1.47) | NA | NA | .0026b |
| MTT | 0.00 | 4.91 (4.00–5.63) | 5.64 (4.82–6.30) | NA | NA | .43 |
Note:—NA, not applicable.
↵a Bonferroni-corrected P < .017 is considered statistically significant. Age was considered a confounding factor for comparing RRMS vs HC and SPMS vs HC; age, EDSS, and disease duration were considered confounding factors for comparing SPMS vs RRMS. All volumes are in cubic centimeters; CBF, milliliter/100 gram/meter; CBV, milliliter/100 gram; MTT, second.
↵b Significant.