Table 3:

Cox proportional hazards model of selected CT texture parameters for predicting local failure

Texture Parameter	Univariate Analysis (n = 62)			Multivariate Analysis^{^a} (n = 47)
Texture Parameter	HR	95% CI	P Value	HR	95% CI	P Value
Histogram
Mean	2.79	1.21–6.46	.019^{^b}	1.74	0.62–4.88	.295
SD	5.69	2.39–13.53	<.001^{^b}	2.56	0.66–10.00	.176
Geometric mean	4.08	1.50–11.07	.002^{^b}	4.68	1.21–18.11	.026^{^b}
Harmonic mean	3.47	1.17–10.26	.012^{^b}	8.61	2.00–37.19	.004^{^b}
Fourth moment	5.69	2.40–13.53	<.001^{^b}	4.56	1.01–20.48	.048^{^b}
GLRL
SRE	4.58	2.24–13.48	<.001^{^b}	3.75	1.23–13.61	.044^{^b}
LRE	3.63	1.55–8.54	.003^{^b}	2.68	0.67–10.66	.163
GLN	5.61	2.06–15.28	<.001^{^b}	5.72	1.74–18.82	.004^{^b}
RLN	5.69	2.22–14.59	<.001^{^b}	4.16	1.25–16.48	.043^{^b}
RP	3.39	1.32–8.67	.007^{^b}	3.70	0.85–16.21	.082
LGRE	5.06	1.71–14.99	<.001^{^b}	4.84	0.99–24.34	.055
HGRE	3.74	1.61–8.69	.003^{^b}	2.39	0.53–10.83	.260
SRLGE	4.53	1.67–12.32	.001^{^b}	5.94	1.14–24.97	.035^{^b}

Note:—LRE indicates long-run emphasis; RP, run percentage; LGRE, low gray-level run emphasis; HGRE, high gray-level run emphasis.
↵a Models were adjusted for age, sex, smoking, primary tumor stage, primary tumor volume, and HPV status.
↵b Indicates a significant difference (P < .05).