Clinical and radiographic exclusion criteria
| Exclusion Criteria |
|---|
| Identified pathology in the brain |
| Prior intracranial operation |
| Motion or susceptibility artifacts causing image distortion of SyMRI |
| Known developmental delay in language or motor domains requiring therapy |
| Autism spectrum disorder |
| Fixed neurologic deficit related to intracranial disease |
| Spasticity with cerebral cause requiring therapy |
| Chronic epilepsy |
| Significant prematurity (younger than 34 weeks' GA at delivery) |
| Significant macrocephaly (head circumference >97th percentile) |
| Significant microcephaly (head circumference <3rd percentile) |
| Hydrocephalus |
| Head trauma with extra-axial hemorrhage |
| Genetic disorder known to involve brain development |
| Systemic steroid therapy within 1 mo of examination |
Note:—GA indicates gestational age.