Table 1:

Study sample characteristics in the LIFE study at the Pittsburgh site

MRI Study (n = 53)Non-MRI Study (n = 163)P Value
Age (median) (IQR) (yr)76.0 (5.8)79.4 (9.0)<.01a
Race, non-Hispanic white (No.) (%)30 (56.6)124 (76.1)<.01a
Sex, female (No.) (%)42 (79.2)123 (75.5).57
APOE4 allele presenceb (No.) (%)15 (31.9)27 (20.0).10
VEGF (median) (IQR) (pg/mL)414.61 (370.17)–
BDNF (median) (IQR) (pg/mL)19,780.30 (27,492.00)–
Pulse pressure (median) (IQR)53 (13)57 (18).06
Physical activity—daily moderate activity (median) (IQR) (min)24.6 (31.6)18.3 (22.7).05
3MS (median) (IQR)93 (7)92 (9).46
Severe WMH burdenc (No.) (%)11 (20.8)–
No microbleedsd (No.) (%)21 (39.6)–
Confounders
    On antihypertensive medication (No.) (%)39 (73.6)119 (73.0).93
    Hemoglobin levele (median) (IQR) (g/dL)12.7 (1.2)13.2 (2.0).22

  • ↵a Significant.

  • ↵b Available on n = 47 (MRI) and n = 135 (non-MRI).

  • ↵c WMH: rated as 0 = none/mild, 1 = moderate, 2 = severe.

  • ↵d Available on n = 45 due to scan quality or motion; the remaining 24 were split nearly evenly between 1 and >1.

  • ↵e Available on n = 47 (MRI) and n = 139 (non-MRI).