Table 2:

Adjusted mean brain regional volumes (percentage of full intracranial volume)a

Brain RegionControl (n = 10) (mean) (SE)PE (n = 10) (mean) (SE)P Valued
Full intracranial volume (mL)1431.7 (33.6)1495.5 (33.6).201
Cerebellumb8.72 (0.21)9.58 (0.21).010
Frontal lobeb16.62 (0.39)17.08 (0.39).422
Occipital lobeb6.25 (0.18)6.58 (0.18).213
Parietal lobeb9.41 (0.26)9.75 (0.26).364
Temporal lobeb8.98 (0.15)9.65 (0.15).007
Left accumbensc0.03 (0.001)0.03 (0.001).993
Right accumbensc0.03 (0.001)0.03 (0.001).986
Left amygdalac0.09 (0.003)0.10 (0.003).023
Right amygdalac0.11 (0.002)0.12 (0.002).012
Brain stemc1.27 (0.04)1.40 (0.04).015
Left caudatec0.20 (0.01)0.21 (0.01).843
Right caudatec0.20 (0.01)0.21 (0.01).490
Left cerebral cortexc23.25 (0.41)24.39 (0.41).071
Right cerebral cortexc24.42 (0.46)25.39 (0.46).158
Left cerebral white matterc13.42 (0.37)13.96 (0.37).320
Right cerebral white matterc12.17 (0.33)12.85 (0.33).168
Left hippocampusc0.21 (0.01)0.23 (0.01).166
Right hippocampusc0.22 (0.01)0.23 (0.01).247
Left lateral ventriclec0.34 (0.07)0.36 (0.07).873
Right lateral ventriclec0.31 (0.05)0.32 (0.05).941
Left pallidumc0.11 (0.004)0.12 (0.004).327
Right pallidumc0.12 (0.004)0.12 (0.004).257
Left putamenc0.31 (0.01)0.32 (0.01).446
Right putamenc0.34 (0.01)0.34 (0.01).594
Left thalamusc0.36 (0.01)0.38 (0.01).335
Right thalamusc0.41 (0.01)0.42 (0.01).396

  • Note:—SE indicates standard error.

  • ↵a All means were adjusted for age (9.72 yr), height (1.38 m), and weight. (30.39 kg).

  • ↵b Derived from the Montreal Neurological Institute brain atlas.

  • ↵c Derived from the Harvard-Oxford subcortical atlas.

  • ↵d Bonferroni-corrected.