Most up-regulated canonical pathways, determined by IPA
| Canonical Biologic Pathway | No. of Genes Up-Regulated | Genes | No. of Genes Down-Regulated | Gene(s) |
|---|---|---|---|---|
| Dendritic cell maturation | 25 | CD80, CD83, CD86, CD1C, COL10A1, COL1A1, COL1A2, FCGR1B, FCGR2A, HLA-A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, IL15, IL1B, IL1RL2, IL1RN, PIK3CG, PIK3R5, PLCB2, TREM2 | 3 | CREB5, PLCB4, PLCL1 |
| Role of NFAT in regulation of the immune response | 22 | BLNK, BTK, CD80, CD86, FCER1A, FCGR1B, FCGR2A, FOS, GNG2, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, LCP2, LYN, PIK3CG, PIK3R5, PLCB2, SYK | 2 | PLCB4, GNAO1 |
| Antigen-presentation pathway | 12 | CD74, HLA-A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB5 | 0 | NA |
| Altered T-cell and B-cell signaling in rheumatoid arthritis | 17 | CCL21, CD80, CD86, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, IL15, IL1B, IL1RN, SPP1, TLR1, TLR8, TNFSF13B | 0 | NA |
| Atherosclerosis signaling | 19 | ALOX5, CCL2, CCR2, COL10A1, COL1A1, COL1A2, CXCR4, IL8, IL1B, IL1RN, LYZ, MSR1, PDGFB, PDGFC, PDGFD, PLA2G7, PLA2R1, SELE, VCAM1 | 1 | RBP4 |
Note:—NA indicates not applicable; NFAT, nuclear factor of activated T cells.