Summary of published randomized clinical trials of surgery versus coiling for ruptured aneurysms
| Kuopio | ISAT | BRAT | |
|---|---|---|---|
| Period | February 1995 to August 1997 | 1997 to September 2002 | March 2003 to January 2007 |
| Single-center/multicenter | Single | Multicenter | Single |
| Enrollment | <72 hours | <28 days | <14 days |
| Total patients screened | 242 | 9559 | 725 |
| Patients enrolled | 109 | 2143 | 471 |
| Mean age (years) | |||
| Endovascular | 49 | 52 | 54 |
| Surgery | 50 | 52 | 53 |
| No. of patients allocated endovascular | 52 | 1073 | 233 |
| No. of patients allocated surgery | 57 | 1070 | 238 |
| Good grade, n (% of total) | 93 (85.3) | 2018 (94.2) | 380 (80.7) |
| Poor grade, n (% of total) | 16 (13.7) | 94 (5.8) | 91 (19.3) |
| Crossovers | |||
| From endovascular to surgery | 12 | 9 | 75 |
| From surgery to endovascular | 4 | 38 | 4 |