Conventional MRI features in patients with pediatric CIS and pediatric MS
| Conventional MRI Features | MRI at the Time of Presentation | MRI at the Time of Diagnosis | ||
|---|---|---|---|---|
| MCIS | PCISWOE | PCISWE | RRMS | |
| Lesion location | ||||
| Gray matter cortex | 0 | 0 | 2 | 3 |
| BG and thalamus | 0 | 2 | 6 | 12 |
| Subcortical | 0 | 5 | 8 | 19 |
| Periventricular | 1 | 7 | 4 | 20 |
| Perpendicular to CC | 0 | 2 | 2 | 16 |
| Internal capsule | 0 | 1 | 2 | 7 |
| Abutting the LV | 0 | 0 | 0 | 10 |
| Cerebellum | 0 | 0 | 4 | 12 |
| Brain stem | 0 | 4 | 4 | 12 |
| Spinal cord | 2 | 3 | 0 | 13 |
| Optic nerve | 6 | 0 | 2 | 0 |
| No. of T2 lesions in the brain (range) | 0–1 | 5–46 | 1–22 | 2–136 |
| No. of T2 lesions in the SC (range) | 0–2 | 0–7 | 0–7 | 0–11 |
| Lesion characteristics | ||||
| Well-defined lesions | 4 | 1 | 16 | |
| Diffuse | 1 | 8 | 10 | 22 |
| Ovoid | 0 | 7 | 4 | 20 |
| Irregular-shaped | 0 | 6 | 9 | 19 |
| Confluent | 0 | 1 | 1 | 6 |
| Tumorlike | 1 | 0 | 4 | 5 |
| Gd enhancement | 6 | 1 | 1 | 6 |
| T1 black hole | 0 | 0 | 0 | 11 |
Note:—BG indicates basal ganglia; LV, lateral ventricle; SC, spinal cord; Gd, gadolinium; CC, corpus callosum.