Summary of main regions exhibiting reduced anisotropy and increased diffusivity in patients with SCA compared with the control population
| WM Tract | Anisotropy | Diffusivity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| EAR | FA | MO | RD | MD | ||||||
| NL | MG | NL | MG | NL | MG | NL | MG | NL | MG | |
| Bilateral | ||||||||||
| Corpus callosum (body) | − | + | − | + | − | + | − | + | − | + |
| Corpus callosum (genu) | − | + | − | +, mostly posterior | − | +, mostly posterior | − | + | − | + |
| Corpus callosum (splenium) | − | + | − | NS | − | − | − | + | − | + |
| Centrum semiovale | + | + | + | + | NS | + | − | + | − | + |
| Unilateral | ||||||||||
| Inferior fronto-occipital fasciculus (R) | − | NS | − | + | − | − | − | + | − | + |
| SLF(R) | − | − | − | − | − | − | NS | + | NS | + |
| SLF(L) | − | − | − | NS | − | − | NS | + | NS | + |
Note:—+ indicates significant at the default confidence level (95%); −, not significant at this level; L, left; MG, patients with mild gliosis; NL, radiologically normal patients; NS, trend toward significance (detectable at reduced confidence level); R, right; SLF: superior longitudinal fasciculus.