Significant clusters of correlation between cord atrophy and aging revealed by voxel-based analyses with different smoothing optionsa
| Smoothing-Kernel Width | Peak Locations | P Value | T Value | κ | R | % Voxels | % Voxels |
|---|---|---|---|---|---|---|---|
| AP | R-L | ||||||
| 0.5 × 0.5 × 0.5 mm3 | AR-C5 | <.001 | 3.9 | 31 | −0.41 | 31/0 | 6/25 |
| 1 × 1 × 1 mm3 | AR-C4 | <.001 | 3.8 | 32 | −0.40 | 73/0 | 8/65 |
| AR-C5 | <.001 | 3.9 | 41 | −0.40 | |||
| 1.5 × 1.5 × 1.5 mm3 | AR-C4 | <.001 | 3.7 | 47 | −0.39 | 103/0 | 16/87 |
| AR-C5 | <.001 | 3.8 | 56 | −0.40 | |||
| 2 × 2 × 2 mm3 | AR-C4 | <.001 | 4.2 | 76 | −0.44 | 140/0 | 26/115 |
| AL-C5 | <.001 | 4.1 | 64 | −0.42 | |||
| 2.5 × 2.5 × 2.5 mm3 | AL-C4 | <.001 | 4.5 | 91 | −0.46 | 149/0 | 33/116 |
| AL-C5 | <.001 | 4.1 | 58 | −0.42 | |||
| 0.5 × 0.5 × 1 mm3 | AR-C5 | <.001 | 3.9 | 29 | −0.40 | 29/0 | 5/24 |
| 1 × 1 × 2 mm3 | AR-C4 | <.001 | 3.8 | 42 | −0.39 | 89/0 | 13/76 |
| AR-C5 | <.001 | 3.8 | 47 | −0.40 | |||
| 1.5 × 1.5 × 2.5 mm3 | PR-C1/C2 | <.001 | 3.6 | 20 | −0.37 | 117/20 | 23/114 |
| AR-C4 | <.001 | 3.7 | 52 | −0.39 | |||
| AR-C5 | <.001 | 3.8 | 65 | −0.40 | |||
| 2 × 2 × 3 mm3 | AR C4 | <.001 | 4.1 | 150 | −0.43 | 150/0 | 35/115 |
| AL C5 | <.001 | 4.3 | −0.45 |
↵a Multiple regression with age corrected for sex and total cord volume, P < .001; uncorrected for multiple comparisons, cluster extent κ ≥ 20.