Clinical and radiologic findings in the two study groups
| Ischemic Leukoaraiosis (n = 50) | CADASIL (n = 19) | |
|---|---|---|
| Clinical characteristics | ||
| Age (yr ± SD) | 69.8 ± 9.8 (range, 47–86) | 47.3 ± 12.2 (range, 21–69) |
| Males | 32 (64%) | 8 (42%) |
| Hypertension | 40 (80%) | 1 (5%) |
| Diabetes mellitus | 6 (12%) | None |
| Anti-platelet therapy | 46 (92%) | 15 (79%) |
| Anti-coagulant therapy | None | 2 (10%) |
| Global cognitive function | ||
| MMSE score 28–30 | 25 (50%) | 16 (84%) |
| MMSE score 24–27 | 14 (28%) | 3 (16%) |
| MMSE score <24 | 7 (14%) | None |
| MR imaging findings | ||
| Confluent changes (score of 3 on Fazekas scale) | 43 (86%) | 17 (90%) |
Note.—CADASIL indicates cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; MMSE, Mini-Mental State Examination.