TABLE 1:

Mean diffusivity histogram-derived measures obtained from fluid-attenuated and standard data sets of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and healthy control participants

Fluid-Attenuated Mean (SD)Standard Mean (SD)
CADASILWBPAverage D̄ (10−3 mm2/s)0.807 (0.054)0.935 (0.074)*
Peak location (10−3 mm2/s)0.728 (0.024)0.764 (0.043)**
NABAverage D̄ (10−3 mm2/s)0.762 (0.025)0.901 (0.056)*
Peak location (10−3 mm2/s)0.727 (0.024)0.764 (0.042)**
LesionsAverage D̄ (10−3 mm2/s)1.210 (0.060)1.252 (0.073)*
Peak location (10−3 mm2/s)1.125 (0.117)1.140 (0.165)ns
ControlWBPAverage D̄ (10−3 mm2/s)0.689 (0.015)0.798 (0.027)*
Peak location (10−3 mm2/s)0.669 (0.017)0.667 (0.035)ns

  • Note.—CADASIL indicates cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; WBP, whole brain parenchyma; NAB, normal appearing brain tissue; D̄ mean diffusivity. Note that control NAB is congruent with control WBP.

  • * P < .001.

  • ** P < .01.

  • ns, Not significant, within group paired t test comparing standard and fluid-attenuated images.