TABLE 1:

Mean diffusivity (D′ × 10⁻³ mm²/s)

D′	Patient 1				Patient 2				Patient 3				Control Participants		Mean +1 SD	Mean +2 SD
D′	Mean	SD	ROI	T2	Mean	SD	ROI	T2	Mean	SD	ROI	T2	Mean	SD	Mean +1 SD	Mean +2 SD
PLIC-l	0.65	0.02	9	0	0.70	0.08	9	1	0.70	0.05	9	1	0.65	0.02	0.67	0.68
PLIC-r	0.67	0.03	8	0	0.69	0.06	9	1	0.68	0.06	9	1
CSO-l	0.66	0.03	29	0	0.78	0.08	36	1	0.70	0.03	51	0	0.66	0.02	0.68	0.70
CSO-r	0.66	0.02	25	0	0.77	0.10	38	1	0.71	0.03	52	0
FWM-l	0.77	0.04	62	0	0.74	0.04	80	0	0.75	0.05	100	0	0.74	0.02	0.76	0.78
FWM-r	0.77	0.04	80	0	0.74	0.05	103	0	0.73	0.06	105	0
PWM-l	0.79	0.08	85	0	1.10	0.36	160	1	0.66	0.09	112	0	0.71	0.02	0.73	0.76
PWM-r	0.82	0.08	75	0	1.08	0.42	206	1	0.71	0.07	158	0
TWM-l	0.82	0.08	93	0	1.13	0.30	91	1	0.81	0.08	100	0	0.77	0.02	0.79	0.80
TWM-r	0.81	0.08	113	0	1.32	0.36	94	1	0.79	0.10	130	0
OWM-l	0.81	0.15	90	0	1.82	0.54	77	1	0.72	0.21	69	0	0.70	0.04	0.73	0.77
OWM-r	0.78	0.17	71	0	1.72	0.53	85	1	0.71	0.12	96	0
GCC-l	0.84	0.30	24	0	0.81	0.12	22	0	0.72	0.20	21	0	0.81	0.09	0.90	1.00
GCC-r	0.83	0.20	18	0	0.80	0.16	20	0	0.68	0.09	26	0
SCC-l	0.78	0.18	28	0	1.92	0.35	16	1	0.63	0.25	27	0	0.73	0.06	0.78	0.84
SCC-r	0.79	0.13	20	0	2.13	0.38	18	1	0.61	0.10	19	0
ALIC-l	0.72	0.06	11	0	0.77	0.04	13	0	0.86	0.10	16	1	0.73	0.05	0.79	0.84
ALIC-r	0.75	0.09	9	0	0.73	0.06	8	0	0.82	0.11	12	1

Note.—D′ indicates isotropic diffusion; ROI, region of interest; T2, T2 value on T2-weighted MR images; -l, on the left side; -r, on the right side; PLIC, posterior limb of the internal capsule; CSO, centrum semiovale; FWM, frontal white matter; PWM, parietal white matter; TWM, temporal white matter; OWM, occipital white matter; GCC, genu corporis callosi; SCC, splenium corporis callosi; ALIC, anterior limb of the internal capsule. Mean diffusivity values for three patients with X-linked adrenoleukodystrophy, indicated as mean values and intra-region of interest SDs (inter-pixel SDs), are compared with those of seven age-matched normal control participants, indicated as mean values and inter-region of interest SDs. Values shown on light gray background are between 1 and 2 SDs of the mean, and values shown on dark gray background are >2 SDs of the mean, compared with values for normal control participants. T2 values are either 0 for T2-weighted images without evidence of demyelination in the specific region or 1 for T2-weighted images with evidence of demyelination.