Effects of Tissue Signature Value, Apparent Diffusion Coefficient Value, and Recombinant Tissue Plasminogen Activator Treatment on Outcome of ≥20% Recovery of Ischemic Lesion at 3 Months: Demonstration of Three-Way Interaction among These Individual Factors Regarding Eventual Recovery in Comparison with the Reference Groups
| Recovery # (N) % | Odds Ratio (95% CI) | Odds Ratio (95% CI) | |||
|---|---|---|---|---|---|
| rt-PA | Signature | rADC (Med) | |||
| No | >4 | <0.79 | 11 (45) 0.24 | MLTR group | 0.12 (0.03, 0.47)* |
| ≥0.79 | 14 (23) 0.61 | 4.27 (1.52, 11.99)* | 0.51 (0.11, 2.3) | ||
| ≤4 | <0.79 | 22 (33) 0.67 | 6.75 (2.6, 17.51)* | 0.81 (0.2, 3.2) | |
| ≥0.79 | 40 (50) 0.80 | 12.67 (4.4, 36.44)* | 1.51 (0.35, 6.45) | ||
| Yes | >4 | <0.79 | 7 (10) 0.70 | 6.82 (1.84, 25.31)* | 0.81 (0.23, 2.86) |
| ≥0.79 | 6 (8) 0.75 | 5.5 (0.87, 34.55) | 0.66 (0.09, 5.02) | ||
| ≤4 | <0.79 | 7 (12) 0.58 | 5.65 (1.56, 20.54)* | 0.68 (0.23, 1.97) | |
| ≥0.79 | 14 (19) 0.74 | 8.37 (2.12, 33.02)* | LLTR group | ||
| ADC (Med) | |||||
| No | >4 | <609 μm2/s | 11 (46) 0.24 | MLTR group | 0.13 (0.03, 0.52)* |
| ≥609 μm2/s | 14 (22) 0.64 | 4.22 (1.65, 10.79)* | 0.57 (0.14, 2.31) | ||
| ≤4 | <609 μm2/s | 22 (30) 0.73 | 9.31 (2.8, 30.99)* | 1.26 (0.29, 5.5) | |
| ≥609 μm2/s | 40 (53) 0.75 | 9.09 (3.33, 24.83)* | 1.23 (0.3, 4.94) | ||
| Yes | >4 | <609 μm2/s | 7 (9) 0.78 | 10.18 (1.91, 54.34)* | 1.37 (0.28, 6.72) |
| ≥609 μm2/s | 6 (9) 0.67 | 3.73 (0.71, 19.65) | 0.5 (0.08, 3.27) | ||
| ≤4 | <609 μm2/s | 9 (14) 0.64 | 6.27 (1.47, 26.74)* | 0.84 (0.24, 2.99) | |
| ≥609 μm2/s | 12 (17) 0.71 | 7.42 (1.92, 28.64)* | LLTR group |
Note.—rt-PA indicates recombinant tissue plasminogen activator; rADC, relative apparent diffusion coefficient; Med, median; Reference, reference group.
* P < .05 compared with the reference group using the generalized estimation equations approach considering the correlation among sections and among tissues.