TABLE 4:

Clinical information for 72 patients with intra-axial lesions

InformationNeurodegenerative (n = 72)Leukoencephalopathy-like (n = 46)*Vascular Pattern (n = 8)*
Age at diagnosis of LCH
 Mean2 y 4 mo2 y 8 mo3 y 1 mo
 Rangebirth to 40 ybirth to 40 y1 y 5 mo to 20 y
Age at diagnosis of CNS disease
 Mean9 y13 y 4 mo13 y
 Range2 y 4 mo to 52 y2 to 47 y3 to 22 y
Chemotherapy before CNS disease
 No. of patients62326
 Mean age2 y 4 mo2 y 8 mo2 y
 Age range3 to 40 y6 mo to 40 y1 y 5 mo to 5 y 3 mo
Cranial radiotherapy before CNS disease
 No. of patients1591
 Mean age3 y 7 mo5 y 6 mo1 y 5 mo
 Age range1 y 5 mo to 27 y2 y 7 mo to 28 yNot applicable
Neurologic symptoms
 None18170
 Subtle1560
 Severe39238
Observation time
 Mean8 y 3 mo8 y 6 mo10 y 7 mo
 Range1 mo to 20 y1 mo to 20 y3 to 17 y

  • * All patients had additional neurodegenerative lesions.