Review of pathologically proved CJD cases with positive DW imaging findings reported in the literature
| Report | Patient Age (y)/Sex | Time of Study after Onset of Symptoms (mo) | Location of Hyperintensity on DW Image | MR Imaging (T2/FLAIR) Abnormalities | Others Findings |
|---|---|---|---|---|---|
| Demaerel et al 1997 (6) | 68/F | 1 | Cortex | (+) T2 | (+) EEG |
| Bahn et al 1997 (7) | 61/F | 4 | Basal ganglia/cortex | (+/−) FLAIR> T2 | (−) EEG |
| Samman et al 1999 (8) | 68/F | 8 | Basal ganglia/cortex | (+) T2 | (−) EEG (−) CSF |
| Demaerel et al 1999 (9) | 68/F | 0.75, 1.75 | Basal ganglia/cortex | (+/−) T2 | NP |
| 65/M | 2 | Basal ganglia/cortex | (−) | NP | |
| 59/F | 1, 1.5 | Basal ganglia/cortex | (−) | NP | |
| Bahn et al 1999 (10) | 61/F | 7 | Basal ganglia | (+) FLAIR > T2 | (+) CSF |
| 53/F | 1 | Basal ganglia | (+) T2 | NP | |
| 64/F | 2 | Cortex | (+/−) FLAIR | (+) CSF | |
| Yee et al 1999 (11) | 69/M | 1.5 | Cortex | (−) | (+) EEG |
| Kropp et al 2000 (12) | 68/F | 9 | Basal ganglia/cortex | (+/−) | (+) CSF |
| 70/F | 7 | Basal ganglia | (+/−) | (+) CSF | |
| 58/M | 5 | Basal ganglia | (+/−) | (+) CSF | |
| 48/M | 3 | Basal ganglia/cortex | (+/−) | (+) CSF | |
| 68/F | 1 | Basal ganglia | (+/−) | (+) CSF | |
| Romi et al 2000 (13) | 54/F | 8 | Basal ganglia/co rtex | (−) | (−) EEG |
| Current case | 63/M | 4, 5.5, 6 | Cortex | (+/−) FLAIR | (+) EEG (−) CSF |
Note.—CSF markers used were 14-3-3 protein or neuron-specific enolase. (+) indicates positive findings; (+/−), subtle findings; (−), negative findings; NP, no other studies were performed.