Clinical and MRS data: changes with time (6 months)a
| ALS-L (n = 7) Baseline → Follow-Up | ALS-B (n = 9) Baseline → Follow-Up | PMA (n = 10) Baseline → Follow-Up | Controls (n = 12) Baseline → Follow-Up | |
|---|---|---|---|---|
| VC (%) | 106.9 → 101.9 | 101.4 → 84.4.013 | 101.0 → 91.3.028 | 114.6 → 117.2 |
| ALSFRS-R | 42.6 → 39.3.026 | 41.3 → 36.4.011 | 41.8 → 36.8.008 | 48.0 → 47.8 |
| Finger tapping/sb | 3.32 → 2.49.046 | 4.29 → 3.77.038 | 4.83 → 4.28 | 5.10 → 4.98 |
| Foot tapping/sb | 2.80 → 2.13 | 3.17 → 2.73 | 2.37 → 1.88 | 3.44 → 3.74 |
| NAAx | 8.79 → 9.07 | 8.65 → 8.21 | 9.72 → 9.18.022 | 9.32 → 9.25 |
| Glx | 8.54 → 7.50 | 8.12 → 8.54 | 7.72 → 8.00 | 8.42 → 8.07 |
| mIns | 4.29 → 4.54 | 4.25 → 4.61 | 4.30 → 3.92 | 3.93 → 3.90 |
| NAAx/mIns | 2.11 → 2.04 | 2.08 → 1.86 | 2.37 → 2.39 | 2.45 → 2.40 |
a Values are means. P values (superscript) result from the Wilcoxon paired test for nonparametric data. Statistical significance was set at P < .05.
b Finger- and foot-tapping speed: (L + R) / 2.