Table 1:

Thalamic volumetry and DTI findings from the GM with and without the thalamus, at study entry and after 15 months in healthy controls and patients with PPMSa

VariablesHealthy ControlsPatients with PPMSP Value
NTV
    Baseline6.11 (0.48)4.11 (0.95)<0.001
    % Change−1.9 (3.1)−4.7 (6.2)0.39
    Pan.s.<.0001
Thalamic MD
    Baseline0.87 (0.04)1.08 (0.16).002
    % Change+4.0 (8.7)+2.0 (10.2).61
    Pbn.s.<.0001
Thalamic FA
    Baseline0.23 (0.01)0.21 (0.02).002
    % Change−5.0 (7.1)−12.2 (7.1).01
    Pbn.s.<.0001
GM without thalami MD
    Baseline1.02 (0.04)1.08 (0.06).005
    % Change+1.0 (2.4)+2.0 (6.2)n.s
    Pbn.s.n.s.
GM without thalami FA
    Baseline0.15 (0.06)0.14 (0.11)n.s.
    % Change−6.1 (12.0)−16.1 (16.1).06
    Pbn.s..009

  • a Values are means ± SDs in parentheses.

  • b Pair-wise comparisons versus baseline values (the text for statistical analysis).