Model inputs analysis for base case and range of univariate sensitivity
| Model Input | Aggressive NIR Rx (range) | Best Medical Therapy (range) | Reference |
|---|---|---|---|
| Recanalization rate | 84% (63%–100%) | 24% (14%–50%) | Rha and Saver, 20079 |
| Symptomatic ICH | |||
| With recanalization | 6.2% (4%–14%) | 2.0% | Smith et al, 200812; Furlan et al, 199915 |
| Without recanalization | 17.3% | 5.5% | Smith et al, 200812; Furlan et al, 199915 |
| Relative utility | |||
| Permanent mild disability (mRS 0–2) | 0.85 | 0.85 | Earnshaw et al, 200619 |
| Permanent moderate-severe disability (mRS 3–5) | 0.27 | 0.27 | Earnshaw et al, 200619 |
| Death | 0 | 0 | |
| Costs | |||
| With ICH complication | $28,087 | $10,245 | Medicare MS-DRG 023 and 06416 |
| Without ICH complication | $19,210 | $4,686 | Medicare MS-DRG 024 and 06616 |
| Mild disability (annual) | $2,200 | $2,200 | Gage et al, 199529 |
| Moderate-severe disability (annual) | $20,000 | $20,000 | Gage et al, 199529 |
| Discount rate | 3.00% | 3.00% | Gold et al, 199613 |