Table 2:

Correlations between age and regional gray matter volumes

Location	Sex	Brodmann Areas	P_FWECorrected^*	Size of Cluster^†	Peak Z-Score^‡	Coordinates X, Y, Z^§
Highest gray matter decrease as a function of age
Right middle and superior temporal gyri	Overall sample	21, 22, 42	0.040	570	3.78	67, −9, 6
Right middle and superior temporal gyri	Men	21, 22, 42	0.015	349	4.11	69, −8, −6
Right dorsomedial frontal cortex	Men	10, 11	0.048	95	3.38	6, 68, −3
Right orbitofrontal cortex	Men	10, 11	0.038	99	3.72	26, 64, −10
Left orbitofrontal cortex	Men	10, 11	0.042	103	3.62	−6, 66, −10
Left parahippocampal gyrus	Men		0.042	34	3.22	−14, −1, −15
Right amygdala	Men		0.036	17	2.83	18, 1, −15
Left amygdala	Men		0.015	40	3.12	−14, −1, −13
Lowest gray matter decrease as a function of age
Right dorsolateral frontal cortex	Men	6	0.031	154	3.74	24, 3, 55

Note:—FWE indicates family-wise error.
* Statistical significance after correction for multiple comparisons; inferences made at the level of individual voxels (FWE correction).
† Number of contiguous voxels that surpassed the initial threshold of P <0.01 (uncorrected) in the statistical parametric maps.
‡ Z-scores for the voxel of maximal statistical significance.
§ Talairach and Tournoux coordinates of the voxel of maximal statistical significance within each cluster.