Comparison of patients with and without arterial reocclusion
| Total (n = 91) | Reocclusion (n = 16) | No Reocclusion (n = 75) | P Value | |
|---|---|---|---|---|
| Mean age (years) | 67 ± 15 | 70 ± 14 | 66 ± 16 | .58 |
| Male patients (No., %) | 48 (53) | 8 (50) | 40 (53) | .81 |
| Occlusion site: | .92 | |||
| MCA | 48 (53%) | 9 (56%) | 39 (52%) | |
| ICA | 29 (32%) | 5 (31%) | 24 (32%) | |
| ACA | 2 (2%) | 0 (0%) | 2 (3%) | |
| BA | 12 (13%) | 2 (13%) | 10 (13%) | |
| Study protocol* | .18 | |||
| Group 1 | 47 (52%) | 9 (56%) | 38 (51%) | |
| Group 2 | 12 (13%) | 4 (25%) | 8 (11%) | |
| Group 3 | 19 (21%) | 3 (19%) | 16 (21%) | |
| Group 4 | 13 (14%) | 0 (0%) | 13 (17%) | |
| Mean time to treatment (h) | 4.36 ± 2.18 | 4.05 ± 1.27 | 4.42 ± 2.33 | .06 |
| Initial Qureshi grade 0–3B | 53 (58%) | 9 (56%) | 44 (59%) | .86 |
| Initial Qureshi grade 4A-5 | 38 (42%) | 7 (44%) | 31 (41%) | |
| Final recanalization† | <.01 | |||
| None | 19 (21%) | 2 (13%) | 17 (23%) | |
| Partial | 41 (45%) | 13 (82%) | 28 (37%) | |
| Complete | 29 (32%) | 1 (6%) | 28 (37%) | |
| Symptomatic ICH (No.) | 10 | 3 | 7 | .46 |
| Median initial NIHSS score | 19 (±8) | 19 (±7) | 19 (±8) | .90 |
| Median 24-hour NIHSS score | 18 ± 13 | 22 (±11) | 17 (±13) | .18 |
| Median 7-day NIHSS score | 18 ± 16 | 25 (±16) | 17 (±16) | .06 |
| Favorable mRS‡ at 1–3 months (No., %) | 29 (32) | 1 (6) | 28 (37) | .02 |
| Favorable 1–3 mRS at 1–3 months among treatment responders§ (n = 70) | 24/70 (34%) | 1/16 (6%) | 23/56 (41%) | .01 |
Note:—MCA indicates middle cerebral artery; ICA, internal carotid artery; ACA, anterior cerebral artery; BA, basilar artery; h, hour; ICH, intracerebral hemorrhage; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.
* Group 1, IA reteplase and MTD; group 2, EKOS MicroLysUS North American trial; group 3, MTD following IV thrombolysis; group 4, IA reteplase and IV abciximab (FDA IND 9180).
† Defined as ≤2.
‡ Data were missing on 2 patients.
§ Patients who never demonstrated recanalization were excluded from the analysis.