Demographics, quantitative CT measurements, and categoric variables in patients with Graves ophthalmopathy, with and without ON*
Graves Ophthalmopathy | ON | Without ON | P Value |
---|---|---|---|
Demographics | |||
No. orbits | 32 | 50 | |
Age | 55.9 ± 11.5 (39–78) | 44.7 ± 11.0 (28–65) | |
Sex (male, female) | 14 M, 18 F | 20 M, 30 F | |
Bony confines | |||
Bony orbital angle (degrees) | |||
Orbital rim | 42.4 ± 2.5 (39–49) | 42.2 ± 2.4 (37–51) | <.727 |
Medial wall | -0.1 ± 5.7 (−8–12) | −3.6 ± 5.2 (−13–12) | <.006 |
Lateral wall | 6.7 ± 3.0 (1–13) | 4.7 ± 2.5 (1–11) | <.002 |
Total angular change | 6.6 ± 7.5 (−3–20) | 1.1 ± 6.5 (−8–17) | <.001 |
Orbital apex | 49.0 ± 8.2 (38–65) | 43.3 ± 7.4 (30–59) | <.002 |
Length of lateral wall (mm) | 44.1 ± 2.9 (35.7–48.9) | 42.5 ± 3.2 (33.7–47.5) | <.022 |
Extraoccular muscles (mm) | |||
Maximum muscle diameter | |||
Medial rectus | 7.2 ± 1.8 (3.8–10.5) | 4.8 ± 1.8 (2.6–10.0) | <.0005 |
Lateral rectus | 4.9 ± 1.5 (2.3–8.2) | 3.8 ± 0.9 (2.1–6.4) | <.0005 |
Superior muscle group | 6.5 ± 1.8 (3.6–9.5) | 4.9 ± 1.7 (2.6–8.7) | <.0005 |
Inferior rectus | 7.1 ± 2.0 (3.2–12.8) | 5.0 ± 1.6 (2.6–9.5) | <.0005 |
Superior oblique | 3.0 ± 0.7 (1.8–4.5) | 2.8 ± 0.7 (1.8–4.4) | .212 |
MDI | 29.0 ± 5.2 (21.1–42.3) | 21.2 ± 4.8 (14.3–32.3) | <.0005 |
Medial rectus bulk from IZ line | 14.0 ± 3.9 (5.4–21.0) | 12.3 ± 3.4 (6.0–21.2) | .049 |
Lateral rectus bulk from IZ line | 16.0 ± 3.0 (10.8–21.2) | 14.8 ± 2.8 (10.7–21.1) | .084 |
Neurovascular structures | |||
Proptosis from IZ line | 2.6 ± 2.7 (−3.5–7.0) | 3.5 ± 4.0 (−4.6- 12.7) | .200 |
Optic nerve stretch | 40.8 ± 3.2 (35.0–47.9) | 39.7 ± 4.1 (30.7–46.6) | .243 |
Optic nerve sheath | |||
Retrobulbar | 5.7 ± 0.7 (4.2–7.2) | 5.8 ± 0.9 (4.0–8.1) | .464 |
Waist | 3.7 ± 0.6 (2.4–5.2) | 3.6 ± 0.7 (1.6–5.5) | .703 |
Superior ophthalmic vein | 1.9 ± 0.4 (1.2–2.7) | 1.8 ± 0.4 (1.2–2.9) | .273 |
Apical crowding | 3 (1–3) | 1 (0–3) | <.0005† |
Presence of intracranial fat prolapse | 11 (34.4%) | 13 (26.0%) | .416‡ |
Note:—IZ line indicates interzygomatic line; ON, optic neuropathy; MDI, muscle diameter index.
* Descriptive statistics presented are mean ± SD (range) and count (%) for the presence of intracranial fat prolapse. All mean quantitative CT measurements between the 2 groups are compared using the Student 2-tailed t test. Statistical significance is defined at P < .05.
† The categoric variables are compared using the Mann-Whitney U test. Statistical significance is defined at P < .05.
‡ The categoric variables are compared using the χ2 square test. Statistical significance is defined at P < .05.