Clinical findings in patients with multiple sclerosis and normal MR imaging scan of the brain
| Gender | Age at Investigation, Years | Onset | Disease Duration, Years | Course | EDSS, Points | Bouts (n) during 2 Years before MR Spectroscopy | Spinal MR Imaging |
|---|---|---|---|---|---|---|---|
| F | 45 | Sensory bout | 5 | RR | 1.0 | 0 | One thoracic lesion |
| F | 52 | Optic neuritis | 9 | RR | 1.0 | 0 | Negative (only cervical MR imaging performed) |
| F | 21 | Sensory bout | 4 | RR | 1.5 | 0 | Not done |
| F | 58 | Sensory bout | 5 | RR | 2.0 | 0 | Negative |
| F | 46 | Sensory bout | 10 | RR | 2.0 | 4 | Negative |
| F | 38 | Sensory bout | 6 | RR | 2.0 | 1 | One cervical lesion |
| F | 50 | Optic neuritis | 11 | RR | 2.0 | 4 | Negative |
| F | 59 | Optic neuritis | 16 | RR | 2.5 | 0 | Not done |
| F | 49 | Optic neuritis | 6 | RR | 3.0 | 1 | Negative |
| F | 51 | Sensory bout | 12 | SP | 3.0 | 0 | Negative |
| M | 36 | Sensory bout | 15 | SP | 3.0 | 3 | Not done |
| M | 57 | Optic neuritis | 10 | SP | 5.0 | 0 | One unspecific thoracic lesion |
| F | 62 | Motor bout | 21 | SP | 5.5 | 0 | Negative |
| M | 57 | Motor bout | 14 | SP | 6.5 | 0 | Negative |
| Mean 48.6 (21–62) | Mean 10.2 (4–21) | Mean 2.9 (1–6.5) |
Note:—Mean values are shown as a geometric mean. F indicates female; M, male; EDSS, Expanded Disability Status Scale; RR, relapsing-remitting; SP, secondary-progressive.