Gadolinium concentration (μg/g) in rat organ tissue after IV 0.1 mmol/mL/kg gadobenate dimeglumine and gadopentetate dimeglumine
| Tissue | Gd-BOPTA | Gd-DTPA | ||||||
|---|---|---|---|---|---|---|---|---|
| 5 Minutes | 30 Minutes | 1 Hour | 2 Hours | 5 Minutes | 30 Minutes | 1 Hour | 2 Hours | |
| Brain tumor | 100.33 ± 7.91 | 70.21 ± 1.22 | 60.18 ± 2.31 | 40.93 ± 1.83 | 70.39 ± 8.75 | 50.92 ± 6.37 | 40.31 ± 7.42 | 30.22 ± 4.91 |
| Peritumoral tissue | 3.63 ± 0.19 | 3.45 ± 0.29 | 3.40 ± 0.57 | 2.73 ± 0.31 | 3.51 ± 0.22 | 3.30 ± 0.46 | 2.97 ± 0.11 | 2.58 ± 0.27 |
| Normal brain | 4.21 ± 0.69 | 3.61 ± 0.77 | 3.51 ± 0.86 | 3.08 ± 0.82 | 3.82 ± 0.41 | 3.54 ± 0.52 | 3.10 ± 0.42 | 2.71 ± 0.62 |
| Blood | 270.13 ± 29.57 | 81.16 ± 12.31 | 40.49 ± 8.29 | 8.27 ± 0.76 | 229.61 ± 42.73 | 69.02 ± 10.32 | 34.42 ± 6.86 | 7.03 ± 1.87 |
| Liver | 570.12 ± 92.71 | 397.85 ± 49.29 | 149.71 ± 29.62 | 132.46 ± 44.29 | 480.46 ± 78.02 | 327.17 ± 62.34 | 123.37 ± 36.63 | 107.22 ± 46.29 |
| Kidney | 897.28 ± 62.01 | 730.65 ± 88.72 | 590.47 ± 70.91 | 420.16 ± 82.66 | 843.23 ± 97.34 | 793.17 ± 54.71 | 612.23 ± 82.67 | 452.17 ± 93.68 |
| Spleen | 88.38 ± 6.29 | 84.63 ± 9.29 | 60.71 ± 8.65 | 46.32 ± 6.23 | 86.58 ± 3.87 | 80.47 ± 6.28 | 59.23 ± 7.39 | 43.79 ± 5.99 |
| Muscle | 87.15 ± 11.87 | 57.68 ± 10.21 | 14.32 ± 2.76 | 5.37 ± 0.27 | 79.17 ± 2.38 | 48.79 ± 8.66 | 11.73 ± 2.83 | 4.86 ± 0.78 |