Brain vascular malformations in children with HHT
| ∼Ten percent of patients with HHT have brain VMs (up to 20% of those with ENG variants) |
| Risk of hemorrhagic stroke or SAH in children with HHT is 60 times the risk in children without HHT |
| In cohorts of children with HHT, 3%–5% have intracerebral hemorrhage |
| Rupture risk of brain AVMs in children with HHT is ∼0.7% per lesion per year (5.5 hemorrhages per 1000 child-years) |
| Many brain VMs in children with HHT are asymptomatic until rupture |