Table 3:

Associations of carotid siphon calcification with brain MR imaging findingsa

Carotid Siphon Calcification in PXE
Age- and Sex-Adjusted (n = 50)Multivariable-Adjusted (n = 50)
MR imaging volumes (β [95% CI])
 GM (mL)–17.3 [–39.9–5.2]–16.8 [–39.9–6.4]
 WM (mL)–3. 6 [–27.3–20.2]–4.2 [–28.4–20.0]
 CSF (mL)74.7 [25.5–123.9]c67.1 [18.7–115.5]c
 Cortical thickness (µm)–39.8 [–89.9–10.1]–40.5 [–91.6–10.7]
 WML (mL)6.4 [1.9–11.0]c6.2– [1.6–10.9]b
Brain infarctions (RR [95% CI])
 Lacunar infarctions2.5 [0.98–6.4]2.3– [0.9–6.1]
 All infarctions3.1 [1.3–7.5]b2.8– [1.1–7.0]b

  • ↵a Carotid siphon calcifications are analyzed as 10log 1+ carotid siphon calcification. For carotid siphon calcification, MR imaging volumes and infarctions are adjusted for age and sex (model 1) and age, sex, and hypertension (model 2). P < .05 was statistically significant.

  • ↵b P < .05.

  • ↵c P < .01.