Statistically significant intergroup differences (P < .05) in the left and right hippocampal ROI values
| Hippocampal ROI (Observer A) | Hippocampal ROI (Observer B) | |||||
|---|---|---|---|---|---|---|
| Value (Mean ± Standard Deviation) | P Value | Value (Mean ± Standard Deviation) | P Value | |||
| non-AzD | AzD | non-AzD | AzD | |||
| NODDI parameter | ||||||
| Left ICVF (dimensionless) | ||||||
| Mean | 0.377 ± 0.032 | 0.358 ± 0.031 | .008 | 0.366 ± 0.033 | 0.349 ± 0.033 | .026 |
| 90th percentile | 0.474 ± 0.041 | 0.452 ± 0.047 | .032 | 0.469 ± 0.093 | 0.438 ± 0.049 | .029 |
| DTI parameter | ||||||
| Right MD (mm2/s) | ||||||
| Mean | 0.699 ± 0.030 | 0.715 ± 0.031 | .022 | 0.707 ± 0.031 | 0.723 ± 0.030 | .046 |
| Left MD (mm2/s) | ||||||
| Mean | 0.706 ± 0.033 | 0.726 ± 0.034 | .004 | 0.721 ± 0.038 | 0.739 ± 0.039 | .014 |
| 10th percentile | 0.641 ± 0.032 | 0.666 ± 0.032 | .001 | 0.658 ± 0.035 | 0.676 ± 0.039 | .011 |
| 90th percentile | 0.769 ± 0.042 | 0.787 ± 0.040 | .029 | 0.787 ± 0.058 | 0.803 ± 0.047 | .026 |
| Left AD (mm2/s) | ||||||
| Mean | 0.790 ± 0.035 | 0.812 ± 0.036 | .002 | 0.809 ± 0.043 | 0.829 ± 0.039 | .008 |
| 10th percentile | 0.716 ± 0.033 | 0.739 ± 0.036 | .001 | 0.733 ± 0.038 | 0.753 ± 0.040 | .003 |
| 90th percentile | 0.869 ± 0.045 | 0.887 ± 0.042 | .037 | 0.894 ± 0.069 | 0.912 ± 0.051 | .039 |
| Left RD (mm2/s) | ||||||
| Minimum | 0.531 ± 0.053 | 0.556 ± 0.053 | .028 | 0.543 ± 0.076 | 0.564 ± 0.066 | .044 |
| Mean | 0.663 ± 0.033 | 0.682 ± 0.034 | .006 | 0.676 ± 0.036 | 0.697 ± 0.047 | .013 |
| 90th percentile | 0.730 ± 0.040 | 0.747 ± 0.038 | .038 | 0.745 ± 0.054 | 0.771 ± 0.076 | .027 |
| Volume (mm3) | ||||||
| Left | 3148.913 ± 519.884 | 2872.464 ± 488.542 | .006 | |||
| Right | 3236.159 ± 438.547 | 3015.669 ± 423.202 | .017 | |||