Baseline characteristics of the population and univariate relationships with collateral gradea
| Whole Cohort (n = 209) | Good Collaterals (Grades 3 and 4) (n = 133) | Poor Collaterals (Grades 1 and 2) (n = 76) | P Value | |
|---|---|---|---|---|
| Patient characteristics | ||||
| Age (yr) | 72 (61–80) | 72 (61–81) | 71 (60–80) | .39 |
| Men | 118 (56) | 73 (55) | 45 (59) | .54 |
| Hypertension | 118 (56) | 80 (60) | 38 (50) | .16 |
| Diabetes mellitus | 32 (15) | 23 (17) | 9 (12) | .29 |
| Current smoking | 26 (12) | 15 (11) | 11 (14) | .50 |
| Pre-IVT characteristics | ||||
| NIHSS score | 16 (9–19.5) | 14 (7–18) | 17 (14–21) | <.001 |
| Onset-to-IVT time (min) | 160 (130–193.5) | 158 (127–195) | 161 (135–186) | .67 |
| Pre-IVT MRI | ||||
| Onset-to-MRI time (min) | 123 (96–154) | 122 (94–159) | 124 (101–154) | .74 |
| Occlusion site | .26 | |||
| ICA-T/L | 36 (17) | 22 (17) | 14 (18) | |
| M1 | 124 (60) | 75 (56) | 49 (65) | |
| M2 | 49 (23) | 36 (27) | 13 (17) | |
| DWI volume (mL) | 12 (5–25) | 8 (2–13) | 33 (16–54) | <.001 |
| PWI volumes (mL) | ||||
| Tmax > 4 s | 133 (83–187) | 119 (70–168) | 176 (114–209) | <.001 |
| Tmax > 6 s | 83 (44–127) | 64 (35–108) | 119 (71–166) | <.001 |
| Tmax > 10 s | 31 (13–63) | 18 (8–44) | 61 (34–95) | <.001 |
| HIR | 0.43 (0.30–0.53) | 0.36 (0.22–0.45) | 0.53 (0.46–0.62) | <.001 |
| PWI-DWI mismatch profile | 186 (91%) | 127 (96%) | 59 (81%) | <.001 |
| Mismatch ratio | 5.6 (3.0–11.1) | 8.2 (4.4–18.7) | 3.2 (2.0–5.0) | .001 |
| FVH-DWI mismatchASPECTS | 3 (2–5) | 4 (3–5) | 2 (0–2.75) | <.001 |
| FVHASPECTS | 5 (4–5) | 5 (4–5.5) | 5 (4–5) | .76 |
Note:—HIR indicates Tmax > 10-second/Tmax > 6-second volume; ICA-T/L, ICA T or L occlusion; Mismatch ratio, Tmax > 6-second volume/DWI volume; PWI-DWI mismatch profile, Tmax > 6-second volume >1.8 × DWI volume.
↵a Categoric variables are expressed as number (%), and continuous variables, as median (IQR). Four patients had missing PWI volume data (1 patient with good collaterals and 3 patients with poor collaterals).