PT  - JOURNAL ARTICLE
AU  - Yamada, K.
AU  - Sakai, K.
AU  - Owada, K.
AU  - Mineura, K.
AU  - Nishimura, T.
TI  - Cerebral White Matter Lesions May Be Partially Reversible in Patients with Carotid Artery Stenosis
AID  - 10.3174/ajnr.A1873
DP  - 2010 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1350--1352
VI  - 31
IP  - 7
4099  - http://www.ajnr.org/content/31/7/1350.short
4100  - http://www.ajnr.org/content/31/7/1350.full
SO  - Am. J. Neuroradiol.2010 Aug 01; 31
AB  - SUMMARY: Contrary to the common belief that age-related WMLs (also known as leukoaraiosis) are a progressive condition, a case of partial reversal of WMLs shortly after carotid artery stenting is described. A 75-year-old man presented with frequent TIAs, which were attributed to right ICA stenosis. He subsequently underwent successful carotid artery stenting. Follow-up MR imaging a week after the procedure showed improvement of WMLs in the right cerebral hemisphere. Pixel-by-pixel image analysis showed that the reversed WMLs tended to have higher λ1 and lower signal intensity on b = 0 images compared with nonreversed lesions, but by only approximately 10%. ADCapparent diffusion coefficientBBBblood-brain barrierICAinternal carotid arteryDTIdiffusion tensor imagingDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryλ1axial diffusivityλ2 and λ3radial diffusivityMTTmean transit timeprebeforepostafterrCBFregional cerebral blood flowrCBVregional cerebral blood volumeTIAtransient ischemic attacksWMLwhite matter lesion